Antibacterial, antifungal, antiplasmodial, and cytotoxic activities of Albertisia villosa

Journal of Ethnopharmacology
M-L Lohombo-EkombaO E Kasende

Abstract

Albertisia villosa (Menispermaceae) is a subtropical medicinal plant that is widely used in traditional African medicines against various diseases. Three known bisbenzylisoquinoline alkaloids; cycleanine, cocsoline, and N-desmethylcycleanine have been identified. Cycleanine, the most abundant (85%) of all identified bisbenzylisoquinoline alkaloids, accounts for all of the activity of the crude drug. The biological screening of cycleanine and the root bark alkaloidal extract revealed potent antibacterial, antifungal, antiplasmodial, and cytotoxic activities. These results may partly explain and support the use of Albertisia villosa root barks for the treatment of malaria and other infectious diseases in traditional Congolese medicine.

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Citations

Sep 17, 2011·Parasitology Research·Azucena González-ColomaRafael A Martínez-Díaz
Jan 2, 2003·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·Okuma E Kasende, D de Waal
Oct 14, 2011·Chemical Research in Toxicology·Hua JinJiang Zheng
Feb 26, 2010·Journal of Asian Natural Products Research·Tasleem ArifRajesh Dabur
Oct 27, 2010·Natural Product Reports·Inder Pal Singh, Hardik S Bodiwala
Apr 12, 2015·Journal of Ethnopharmacology·Patrick B MemvangaRichard K Cimanga
Apr 29, 2014·Journal of Ethnopharmacology·Camille DesgrouasEvelyne Ollivier
Aug 5, 2017·Natural Product Research·Diah Anggraini WulandariPuji Budi Setia Asih
Sep 24, 2019·Chemistry & Biodiversity·Walmir E M CunhaJosé G M Costa
Oct 25, 2016·Mycopathologia·Graciliana LopesLígia Salgueiro
Apr 28, 2020·Phytochemistry Reviews : Proceedings of the Phytochemical Society of Europe·Yueping JiangShao Liu
Jun 9, 2020·Evidence-based Complementary and Alternative Medicine : ECAM·Delfina Fernandes HlashwayoCustódio Gabriel Bila
Apr 11, 2009·Chemical Research in Toxicology·Yuya WangJiang Zheng
May 25, 2021·Journal of Ethnopharmacology·William MillikenEimear Nic Lughadha
Jan 11, 2012·Fitoterapia·Maria Francesca CometaLamberto Tomassini

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