Antibacterial, Antiproliferative, and Immunomodulatory Activity of Silver Nanoparticles Synthesized with Fucans from the Alga Dictyota mertensii

Nanomaterials
Marília Medeiros Fernandes-NegreirosHugo Alexandre Oliveira Rocha

Abstract

In this study, we aimed to synthesize silver nanoparticles containing fucans from Dictyota mertensii (Martius) Kützing using an environmentally friendly method and to characterize their structure as well as antiproliferative, immunomodulatory, and antibacterial effects. Fucan-coated silver nanoparticles (FN) were characterized by Fourier-transform infrared analysis, dynamic light scattering, zeta potential, atomic force microscopy, energy dispersive X-ray spectroscopy, and inductively coupled plasma emission spectrometry. They were evaluated for their effect on cell viability, minimum inhibitory bactericidal concentration, and release of nitric oxide and cytokines. The FN were successfully synthesized using an environmentally friendly method. They were size-stable for 16 months, of a spherical shape, negative charge (-19.1 mV), and an average size of 103.3 ± 43 nm. They were able to inhibit the proliferation of the melanoma tumor cell line B16F10 (60%). In addition, they had immunomodulatory properties: they caused an up to 7000-fold increase in the release of nitric oxide and cytokines (IL-10; IL-6 and TNF-α) up to 7000 times. In addition, the FN showed inhibitory effect on Gram-positive and -negative bacteria, with MIC values...Continue Reading

References

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Citations

Jun 14, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Jayachandran VenkatesanMin Suk Shim
Apr 28, 2021·Therapeutic Delivery·Romina MitarotondaMauricio C De Marzi

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Methods Mentioned

BETA
X-ray
dynamic light scattering
Atomic Force Microscopy
AFM
infrared spectroscopy
Scanning Electron Microscopy

Software Mentioned

GraphPad
IRSolution
GraphPadPrism

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