Antibacterial carbazole alkaloids from Clausena harmandiana twigs

Fitoterapia
Wisanu ManeeratSurat Laphookhieo

Abstract

Three new carbazole alkaloids, harmandianamines A-C (1-3), together with fifteen known compounds (4-18) were isolated from the twigs of Clausena harmandiana. The structures were elucidated by spectroscopic methods, including UV, IR, NMR, and MS. The antibacterial activity against Escherichia coli TISTR 780, Salmonella typhimurium TISTR 292, Staphylococcus aureus TISTR 1466 and methicillin-resistant S. aureus (MRSA) SK1 of some isolated compounds was also evaluated. Compound 6 exhibited significant antibacterial activity against MRSA SK1 with an MIC value of 0.25 μg/mL which higher than that of standard drug, vancomycin (MIC value=1 μg/mL) whereas compounds 14 and 5 showed strong activity with MIC values of 4 and 8 μg/mL, respectively. Only compound 14 showed strong antibacterial activity against S. aureus TISTR 1466 with an MIC value of 4 μg/mL.

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Citations

Jun 29, 2013·Journal of Natural Products·Sarot CheenprachaSurat Laphookhieo
Jun 26, 2013·Journal of Asian Natural Products Research·Hong-Bo DongMing-An Wang
May 7, 2014·Journal of Natural Products·De-Yang ShenTian-Shung Wu
Aug 19, 2014·International Journal of Antimicrobial Agents·T P Tim CushnieAndrew J Lamb
Jan 31, 2013·Phytochemistry·Wisanu ManeeratSurat Laphookhieo
May 26, 2020·Natural Product Research·Sirada BoonyaketgosonKongkiat Trisuwan
Sep 22, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Porntip JantamatPloenthip Puthongking
Aug 14, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Bruno CasciaroDeborah Quaglio
Dec 27, 2018·Natural Product Research·Tharita KitisripanyaWaraporn Putalun
Jan 1, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Jing-Hua YangYun-Song Wang
Apr 4, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Solida LongEmília Sousa
Dec 21, 2016·ACS Medicinal Chemistry Letters·Chia-Yi ChengKak-Shan Shia
May 9, 2018·Organic Letters·Ji LiuAaron Aponick

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