Antibacterial Discovery and Development: From Gene to Product and Back

BioMed Research International
Victor FedorenkoEliora Z Ron

Abstract

Concern over the reports of antibiotic-resistant bacterial infections in hospitals and in the community has been publicized in the media, accompanied by comments on the risk that we may soon run out of antibiotics as a way to control infectious disease. Infections caused by Enterococcus faecium, Staphylococcus aureus, Klebsiella species, Clostridium difficile, Acinetobacter baumannii, Pseudomonas aeruginosa, Escherichia coli, and other Enterobacteriaceae species represent a major public health burden. Despite the pharmaceutical sector's lack of interest in the topic in the last decade, microbial natural products continue to represent one of the most interesting sources for discovering and developing novel antibacterials. Research in microbial natural product screening and development is currently benefiting from progress that has been made in other related fields (microbial ecology, analytical chemistry, genomics, molecular biology, and synthetic biology). In this paper, we review how novel and classical approaches can be integrated in the current processes for microbial product screening, fermentation, and strain improvement.

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Citations

Apr 9, 2016·Current Opinion in Biotechnology·Oksana Bilyk, Andriy Luzhetskyy
Jan 3, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Karolina WitekClaus Jacob
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Jul 6, 2018·Applied Microbiology and Biotechnology·Adil Farooq LodhiYulin Deng
Aug 10, 2021·Archives of Microbiology·Zainab AbdelghaniRouba Hage-Sleiman

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Methods Mentioned

BETA
histone acetylation
environmental stress

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