Antibacterial drug discovery in the resistance era

Nature
Eric D Brown, Gerard D Wright

Abstract

The looming antibiotic-resistance crisis has penetrated the consciousness of clinicians, researchers, policymakers, politicians and the public at large. The evolution and widespread distribution of antibiotic-resistance elements in bacterial pathogens has made diseases that were once easily treatable deadly again. Unfortunately, accompanying the rise in global resistance is a failure in antibacterial drug discovery. Lessons from the history of antibiotic discovery and fresh understanding of antibiotic action and the cell biology of microorganisms have the potential to deliver twenty-first century medicines that are able to control infection in the resistance era.

References

Jul 28, 1995·Science·R D FleischmannJ M Merrick
Apr 16, 2002·Molecular Microbiology·R Allyn ForsythJudith W Zyskind
Apr 17, 2003·Proceedings of the National Academy of Sciences of the United States of America·K KobayashiN Ogasawara
Jun 12, 2003·Proceedings of the National Academy of Sciences of the United States of America·Alexis A BorisyCurtis T Keith
Nov 18, 2003·Proceedings of the National Academy of Sciences of the United States of America·Michael A JacobsColin Manoil
Feb 11, 2005·Chemical Reviews·Eric D Brown, Gerard D Wright
Apr 9, 2005·The Journal of Antibiotics·János Bérdy
May 3, 2005·Nature Reviews. Microbiology·Kenn GerdesAnders Løbner-Olesen
Aug 17, 2005·FEMS Microbiology Reviews·Nicolas Autret, Alain Charbit
Jan 21, 2006·Science·Vanessa M D'CostaGerard D Wright
Oct 3, 2006·Journal of Bacteriology·Andrew R JoyceSanjay Agarwalla
Dec 13, 2006·Nature Reviews. Drug Discovery·David J PayneDavid L Pompliano
Feb 6, 2007·Nature Reviews. Microbiology·Gerard D Wright
Feb 12, 2008·Journal of Medicinal Chemistry·Rosemarie O'Shea, Heinz E Moser
Feb 21, 2008·PloS One·Alicia FajardoJosé L Martínez
Mar 28, 2008·Expert Opinion on Investigational Drugs·Michael Gerber, Grit Ackermann
Jun 18, 2009·Chemical Communications : Chem Comm·Warren R J D GallowayDavid R Spring
Aug 20, 2009·ACS Chemical Biology·Jonathan G SwobodaSuzanne Walker
Aug 29, 2009·Science·Michael A Fischbach, Christopher T Walsh
Sep 22, 2009·Trends in Microbiology·Michael A D'EliaEric D Brown
Sep 29, 2009·Nature Chemical Biology·Ranjana PathaniaEric D Brown
Oct 3, 2009·Nature Protocols·Athanasios TheocharidisTom C Freeman
Jan 14, 2010·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Barry I EisensteinRichard H Baltz
Jan 23, 2010·Science·Michael CostanzoCharles Boone
Sep 2, 2010·Microbiology and Molecular Biology Reviews : MMBR·Julian Davies, Dorothy Davies
Dec 8, 2010·Proceedings of the National Academy of Sciences of the United States of America·Seungil HanVeerabahu Shanmugasundaram
Dec 28, 2010·Cell·Robert J NicholsCarol A Gross
Jan 15, 2011·Clinical Microbiology Reviews·Lynn L Silver
Mar 2, 2011·Nature Reviews. Drug Discovery·Ricardo MacarronG Sitta Sittampalam
Apr 26, 2011·Nature Chemical Biology·Linda EjimGerard D Wright
Jun 29, 2011·FEMS Microbiology Reviews·Dan I Andersson, Diarmaid Hughes
Sep 2, 2011·Nature·Vanessa M D'CostaGerard D Wright
Apr 18, 2012·PloS One·Kirandeep BhullarGerard D Wright
Jun 16, 2012·ACS Chemical Biology·Patricia L TaylorGerard D Wright
Sep 1, 2012·Science·Kevin J ForsbergGautam Dantas
Jan 8, 2013·Nature Biotechnology·Mark P BrynildsenJames J Collins
Jan 17, 2013·Nature Communications·Hasan DemirciGerwald Jogl

❮ Previous
Next ❯

Citations

May 31, 2016·Antibiotics·Rainer NikolayKnud H Nierhaus
Jun 16, 2016·Future Medicinal Chemistry·Mariano Andrea ScorciapinoMatteo Ceccarelli
Jul 21, 2016·ACS Synthetic Biology·James D WinklerRyan T Gill
Aug 16, 2016·Journal of Medicinal Chemistry·Bala Kishan GorityalaFrank Schweizer
Oct 22, 2016·Trends in Microbiology·Gerard D Wright
Oct 30, 2016·Expert Review of Molecular Diagnostics·Teresa CimminoJean-Marc Rolain
Oct 30, 2016·Nucleic Acids Research·Baofeng JiaAndrew G McArthur
Mar 3, 2017·Chemical Reviews·Alideertu DongGe Gao
Mar 4, 2017·Journal of Natural Products·Savithri GalappathiePeter J Mahon
Mar 9, 2017·ACS Applied Materials & Interfaces·Jing QinFeng Yan
Apr 11, 2017·Nature Reviews. Microbiology·Terence S CroftsGautam Dantas
Apr 25, 2017·Chemical Reviews·Akinori OkanoDale L Boger
Jan 15, 2017·Biochemical Pharmacology·Sheo B SinghLynn L Silver
Nov 30, 2016·Biochemical Pharmacology·Fernando Santos-BeneitJuan F Martín
Mar 23, 2017·Journal of Medicinal Chemistry·Mihirbaran MandalJing Su
Apr 13, 2017·Expert Opinion on Drug Discovery·Wooseong KimEleftherios Mylonakis
May 20, 2017·Pharmaceutical Biology·Yadira Rufino-GonzálezMario N Martínez-Gordillo
May 27, 2017·ACS Infectious Diseases·Roberta J Melander, Christian Melander
Mar 23, 2017·The Journal of Infectious Diseases·Joanna JammalAmram Mor
Jun 1, 2017·Expert Opinion on Drug Discovery·Tao WangLi-Rong Yang
Jan 11, 2017·Annals of the New York Academy of Sciences·David McAdams
Jan 22, 2017·Environmental Microbiology·Simon Boecker, Roderich D Süssmuth
Nov 23, 2016·Annals of the New York Academy of Sciences·Andrew G McArthur, Kara K Tsang
Jan 27, 2017·Chemical Communications : Chem Comm·Marie E YurkovichPeter F Leadlay
Dec 25, 2016·Chembiochem : a European Journal of Chemical Biology·Anna SchüllerGünter Mayer
Dec 22, 2016·Cell and Tissue Research·Andreas C HockeStefan Hippenstiel
Dec 15, 2016·Bioorganic & Medicinal Chemistry Letters·Peter J CossarAdam McCluskey
Sep 20, 2016·MedChemComm·Jesse A JonesKirk E Hevener
Jul 25, 2017·Microbial Biotechnology·Harald Brüssow
Jun 22, 2017·Journal of Natural Products·Ramesh MuddalaJohn Boukouvalas

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antimicrobial Resistance (ASM)

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.

Antimicrobial Resistance

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.

Related Papers

Journal/ Indiana Dental Association
C H Miller
American Journal of Ophthalmology
Russell N Van Gelder
GMHC Treatment Issues : the Gay Men's Health Crisis Newsletter of Experimental AIDS Therapies
Martin Delaney
McGill Journal of Medicine : MJM : an International Forum for the Advancement of Medical Sciences by Students
Russell BrownPaul D Simoncic
Minnesota Medicine
Anthony Windebank
© 2022 Meta ULC. All rights reserved