Antibacterial effect of hydrogen peroxide-titanium dioxide suspensions in the decontamination of rough titanium surfaces

Biofouling
David WiedmerHanna Tiainen

Abstract

The chemical decontamination of infected dental implants is essential for the successful treatment of peri-implantitis. The aim of this study was to assess the antibacterial effect of a hydrogen peroxide-titanium dioxide (H2O2-TiO2) suspension against Staphylococcus epidermidis biofilms. Titanium (Ti) coins were inoculated with a bioluminescent S. epidermidis strain for 8 h and subsequently exposed to H2O2with and without TiO2nanoparticles or chlorhexidine (CHX). Bacterial regrowth, bacterial load and viability after decontamination were analyzed by continuous luminescence monitoring, live/dead staining and scanning electron microscopy. Bacterial regrowth was delayed on surfaces treated with H2O2-TiO2compared to H2O2. H2O2-based treatments resulted in a lower bacterial load compared to CHX. Few viable bacteria were found on surfaces treated with H2O2and H2O2-TiO2, which contrasted with a uniform layer of dead bacteria for surfaces treated with CHX. H2O2-TiO2suspensions could therefore be considered an alternative approach in the decontamination of dental implants.

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Citations

Mar 17, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Wenjing Song, Shaohua Ge
Jul 31, 2018·International Journal of Biomaterials·Oscar JansonKen Welch
Nov 16, 2018·International Journal of Molecular Sciences·Rafael Delgado-Ruiz, Georgios Romanos
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Dec 8, 2020·Clinical and Experimental Dental Research·Jørgen HugoHanna Tiainen
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Oct 3, 2018·ACS Applied Materials & Interfaces·David WiedmerHanna Tiainen
Jul 8, 2019·ACS Biomaterials Science & Engineering·Sebastian GeißlerHanna Tiainen
Oct 26, 2021·Frontiers in Cellular and Infection Microbiology·Jagjit Singh DhaliwalRubens Ferreira Albuquerque Junior

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Methods Mentioned

BETA
fluorescence microscopy

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NuGel

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