PMID: 7539067Jan 1, 1994Paper

Antibacterial effects of esters of guanidino- and amidino-acids trypsin inhibitors

Journal of Enzyme Inhibition
M KatoM Muramatu

Abstract

Inhibitory effects of various esters of trans-4-guanidinomethylcyclohexanecarboxylic acid and the 4-tert- butylphenyl esters of amidinopiperidine-4-alkanoic, trans-4- amidinocyclohexanealkanoic, trans-4-guanidinoethylcyclohexanecarboxylic and trans-4-guanidinocyclohexanealkanoic acids, all trypsin inhibitors, on the growth of E. coli, B. subtilis, S. aureus and S. epidermidis were examined. 4-tert-Butylphenyl esters strongly inhibited the growth of E. coli and the order of the inhibitory effects correlated with that for the inhibitory effects on proteinase In, which appears immediately before initiation of DNA synthesis in E. coli and closely correlates with the onset of DNA synthesis. No correlation was observed between the inhibitory effects and Ki values for trypsin. The 4-tert-butylphenyl esters also strongly inhibited B. subtilis, S. aureus and S. epidermidis, and the order, of the inhibitory effects on these bacteria roughly coincided with that on E. coli. The order of the inhibitory effects of each ester, on these bacteria was S. epidermidis > S. aureus > B. subtilis > E. coli. Among the esters examined, the biphenyl ester of trans-4-guanidinoethylcyclohexanecarboxylic acid was the most inhibitory on these four bacteria ...Continue Reading

References

Mar 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·M S MeynW Troll
May 15, 1978·Biochemical and Biophysical Research Communications·K Ito
Jan 1, 1986·Annual Review of Biochemistry·J L Campbell
Jun 1, 1984·Journal of Biochemistry·S MoriM Muramatu
May 1, 1981·Archives of Microbiology·O P Srivastava, A I Aronson
Feb 1, 1993·Biological & Pharmaceutical Bulletin·M KatoM Muramatu
Apr 1, 1993·Biological & Pharmaceutical Bulletin·Y KozakiM Muramatu
Oct 15, 1958·Proceedings of the National Academy of Sciences of the United States of America·J Spizizen

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Citations

Mar 7, 2006·Protein Expression and Purification·Jian-Bin YanXue-Yuan Jiang
Jul 29, 1998·Ecotoxicology and Environmental Safety·G ChenA Kettrup
Jan 1, 1996·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·A A al-Jafari

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