Antibacterial effects of human group IIA and group XIIA phospholipase A2 against Helicobacter pylori in vitro

APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica
Heikki T HuhtinenV Jukka O Laine

Abstract

Group IIA phospholipase A2 (PLA2-IIA) is an enzyme which has important roles in inflammation and infection. Recently, a novel human secretory PLA2 called group XIIA PLA2 (PLA2-XIIA) has been identified. Both PLA2-IIA and PLA2-XIIA are bactericidal against Gram-positive bacteria like many other secretory PLA2s. However, PLA2-XIIA is the only known PLA2 displaying significant bactericidal activity against the Gram-negative bacterium Escherichia coli. We examined the antibacterial properties of recombinant human PLA2-IIA and PLA2-XIIA against Helicobacter pylori, a Gram-negative bacterium, in vitro. PLA2-IIA was not bactericidal against H. pylori, whereas PLA2-XIIA effectively killed H. pylori at a concentration of 50 microg/ml but was not bactericidal at concentrations of 0.5 microg/ml and 5 microg/ml.

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Citations

Aug 8, 2008·European Journal of Human Genetics : EJHG·Jesen A FagernessJohanna M Seddon
Dec 30, 2009·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Elena Domingo-GilMariano Esteban
Jul 13, 2011·Journal of Biochemistry·Makoto MurakamiKei Yamamoto
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May 14, 2010·Pediatric Research·Asmaa Abu-MaziadJeffrey C Murray
Aug 23, 2012·Comparative Biochemistry and Physiology. Part D, Genomics & Proteomics·Timo J Nevalainen, João C R Cardoso
May 28, 2014·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Heikki PeuravuoriTimo J Nevalainen
Sep 26, 2013·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Roberto RomeroTinnakorn Chaiworapongsa
Mar 26, 2015·Journal of Lipid Research·Makoto MurakamiYoshitaka Taketomi
Feb 28, 2009·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Tuomas MirttiKalle Alanen
Apr 11, 2007·Journal of the American Chemical Society·Günther H PetersThomas L Andresen

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