Antibacterial Efficacy of Polysaccharide Capped Silver Nanoparticles Is Not Compromised by AcrAB-TolC Efflux Pump

Frontiers in Microbiology
Mitali MishraHarapriya Mohapatra

Abstract

Antibacterial therapy is of paramount importance in treatment of several acute and chronic infectious diseases caused by pathogens. Over the years extensive use and misuse of antimicrobial agents has led to emergence of multidrug resistant (MDR) and extensive drug resistant (XDR) pathogens. This drastic escalation in resistant phenotype has limited the efficacy of available therapeutic options. Thus, the need of the hour is to look for alternative therapeutic approaches to mitigate healthcare concerns caused due to MDR bacterial infections. Nanoparticles have gathered much attention as potential candidates for antibacterial therapy. Equipped with advantages of, wide spectrum bactericidal activity at very low dosage, inhibitor of biofilm formation and ease of permeability, nanoparticles have been considered as leading therapeutic candidates to curtail infections resulting from MDR bacteria. However, substrate non-specificity of efflux pumps, particularly those belonging to resistance nodulation division super family, have been reported to reduce efficacy of many potent antibacterial therapeutic drugs. Previously, we had reported antibacterial activity of polysaccharide-capped silver nanoparticles (AgNPs) toward MDR bacteria. We ...Continue Reading

References

Apr 1, 1997·Clinical Microbiology Reviews·W E Sanders, C C Sanders
May 4, 2004·Journal of Nanobiotechnology·OV Salata
May 26, 2005·The Journal of Antimicrobial Chemotherapy·Keith Poole
Sep 10, 2005·American Journal of Respiratory and Critical Care Medicine·Svetlana GelperinaLeonid Heifets
Mar 24, 2007·Nanomedicine : Nanotechnology, Biology, and Medicine·Jun Sung KimMyung-Haing Cho
Nov 28, 2008·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Helen W BoucherJohn Bartlett
Feb 3, 2009·Experimental and Molecular Pathology·Rajesh Singh, James W Lillard
Apr 26, 2011·Chemistry & Biology·Elena B TikhonovaHelen I Zgurskaya
Aug 17, 2011·International Journal of Nanomedicine·Phong A Tran, Thomas J Webster
Feb 1, 2012·Antimicrobial Agents and Chemotherapy·Astrid PérezGermán Bou
Jul 6, 2012·Clinical Microbiology Reviews·Pranita D TammaLisa L Maragakis
Jul 26, 2012·Future Microbiology·Maria Lina MezzatestaStefania Stefani
Mar 6, 2013·Expert Review of Anti-infective Therapy·Jack N PendletonBrendan F Gilmore
Jul 31, 2013·Advanced Drug Delivery Reviews·Robert Y Pelgrift, Adam J Friedman
Sep 18, 2013·The Journal of Antimicrobial Chemotherapy·Cristian Ruiz, Stuart B Levy
Apr 22, 2014·Nature·Dijun DuBen F Luisi
Jun 1, 2014·Biochemical and Biophysical Research Communications·Jingjing SunAixin Yan
Aug 21, 2014·Advanced Drug Delivery Reviews·Ching-Wen ChenPing-Shan Lai
Nov 2, 2014·Frontiers in Microbiology·Hang YangHongping Wei
Apr 29, 2015·Frontiers in Microbiology·Adrián Rangel-VegaRodolfo García-Contreras
Jun 5, 2015·Frontiers in Microbiology·Anne Davin-Regli, Jean-Marie Pagès
Dec 15, 2015·Nanomedicine : Nanotechnology, Biology, and Medicine·Dávid KovácsMónika Kiricsi
Jan 3, 2016·Nanomedicine : Nanotechnology, Biology, and Medicine·Nelson DuránGerson Nakazato
Oct 25, 2016·Frontiers in Microbiology·Marta Martins, Matthew P McCusker
Jan 14, 2017·Frontiers in Cellular and Infection Microbiology·Margit MahlapuuCamilla Björn

❮ Previous
Next ❯

Methods Mentioned

BETA
surface plasmon resonance
ELISA

Software Mentioned

one
ChemiDoc
Quantity

Related Concepts

Related Feeds

Biofilms

Biofilms are adherent bacterial communities embedded in a polymer matrix and can cause persistent human infections that are highly resistant to antibiotics. Discover the latest research on Biofilms here.

Antimicrobial Resistance

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.

Antimicrobial Resistance (ASM)

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.