Antibacterial Narrow-Band-Gap Conjugated Oligoelectrolytes with High Photothermal Conversion Efficiency

Angewandte Chemie
Bing WangGuillermo C Bazan

Abstract

Two conjugated oligoelectrolytes (COEs), WMG1 and WMG2, were designed with the goal of achieving near infrared absorption and high photothermal conversion efficiency. Specifically, electron-rich thiophene and electron-poor benzo[1,2-c:4,5-c']bis[1,2,5]thiadiazole subunits were introduced into the conjugated core to modulate the optical gap and to reduce the fluorescence emission efficiency. WMG1 and WMG2 show absorption maxima at around 800 nm, which favors tissue penetration. Although relatively small in size, WMG1 and WMG2 exhibit photothermal conversion efficiencies of circa 60 % and 54 %, respectively. WMG1 shows dark toxicity to the Gram positive bacterium B. subtilis and good photothermal killing efficiency toward both B. subtilis and Gram negative E. coli, features that demonstrate the promising potential of the COE molecular design for photothermal applications.

References

Nov 18, 2008·The Journal of Physical Chemistry. C, Nanomaterials and Interfaces·D Keith RoperM Hoepfner
Aug 24, 2010·Accounts of Chemical Research·Pierre M BeaujugeJohn R Reynolds
Aug 1, 2012·Chemical Communications : Chem Comm·Mei ChenNanfeng Zheng
Sep 21, 2013·Advanced Materials·Zhenjiang ZhangChunying Chen
Jun 27, 2014·Chemical Society Reviews·Liming Nie, Xiaoyuan Chen
Sep 27, 2014·Chemical Reviews·Liang ChengZhuang Liu
Apr 8, 2015·Advanced Materials·Hengjing YanGuillermo C Bazan
Jun 6, 2016·Advanced Drug Delivery Reviews·Yu-Wei ChenSan-Yuan Chen
Jul 13, 2016·Journal of the American Chemical Society·Yan LyuKanyi Pu
Aug 16, 2016·International Journal of Molecular Sciences·Alla BucharskayaValery Tuchin
Jan 25, 2017·Advanced Materials·Qinglai YangHongjie Dai
Feb 6, 2017·ACS Applied Materials & Interfaces·Hwan-Jun YoonJi-Ho Park
Feb 14, 2017·Journal of Biomedical Optics·Kenneth J FurdellaJonathan P Vande Geest
Jan 1, 2016·Nanomaterials·Kondareddy CherukulaIn-Kyu Park
Oct 7, 2015·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Guangxue FengBin Liu
Jan 14, 2017·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Yingge ShiYen Wei

❮ Previous
Next ❯

Citations

Mar 13, 2019·Advanced Materials·Erica ZeglioAnna Herland
Jan 31, 2019·Advanced Materials·Bing WangGuillermo C Bazan
Nov 17, 2020·Chemical Society Reviews·Guangxue FengDan Ding
Mar 21, 2021·Drug Discovery Today·Xiao-Lu Weng, Jian-Yong Liu
Mar 14, 2019·Journal of the American Chemical Society·Shunjie LiuBen Zhong Tang
Sep 26, 2019·ACS Applied Materials & Interfaces·Yantao ZhaoYanli Tang
Dec 4, 2020·ACS Applied Materials & Interfaces·Florencia A MongeAlison M Kell

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.