PMID: 9535293Apr 16, 1998Paper

Antibacterial peptides are present in chromaffin cell secretory granules

Cellular and Molecular Neurobiology
M H Metz-BoutigueD Aunis

Abstract

1. Antibacterial activity has recently been associated with the soluble matrix of bovine chromaffin granules. Furthermore, this activity was detected in the contents secreted from cultured chromaffin cells following stimulation. 2. The agents responsible for the inhibition of Gram+ and Gram- bacteria growth are granular peptides acting in the micromolar range or below. In secretory granules, these peptides are generated from cleavage of chromogranins and proenkephalin A and are released together with catecholamines into the circulation. 3. Secretolytin and enkelytin are the best characterized; these two peptides share sequence homology and similar antibacterial activity with insect cecropins and intestinal diazepam-binding inhibitor. For some of the peptides derived from chromogranin A, posttranslational modifications were essential since antibacterial activity was expressed only when peptides were phosphorylated and/or glycosylated. 4. The significance of this activity is not yet understood. It may be reminiscent of some primitive defense mechanism or may serve as a first barrier to bacteria infection during stress, as these peptides are secreted along with catecholamines.

Citations

Jan 24, 2018·Frontiers in Veterinary Science·Chetan SharmaHarsh Panwar
Jun 11, 1998·The Journal of Biological Chemistry·J Ciesielski-TreskaM F Bader
Feb 7, 2001·The Journal of Biological Chemistry·K LugardonM H Metz-Boutigue
Feb 21, 2003·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Anne-Estelle KiefferMarie-Héléne Metz-Boutigue
Feb 3, 2005·Biological Reviews of the Cambridge Philosophical Society·Karen B Helle
Mar 24, 2006·Physiological Genomics·Tiffany A GreenwoodDaniel T O'Connor
Jan 5, 2017·Acta Veterinaria Scandinavica·Thanikul SrithunyaratAnn Pettersson
Aug 25, 2020·Journal of Neuroscience Research·Alden Y HuangChristopher J Evans
Aug 22, 2000·The Prostate·L CarlssonM Stridsberg
Oct 20, 2000·The Journal of Veterinary Medical Science·F SatoN Ishida
Sep 21, 2001·Indian Journal of Pediatrics·M Yaster, D G Nichols
Jul 14, 2001·The Journal of Biological Chemistry·K LugardonM H Metz-Boutigue
Nov 26, 2010·Current Hypertension Reports·Kuixing ZhangDaniel T O'Connor
Dec 13, 2005·American Journal of Veterinary Research·Charles M BoudreauxFrederick M Enright
Jan 1, 2009·Sensors·Olivier LesouhaitierMarc Feuilloley
Nov 20, 2002·Annals of the New York Academy of Sciences·K LugardonM H Metz-Boutigue
Nov 23, 2010·Cellular and Molecular Neurobiology·Karen B Helle
Jul 23, 2002·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Guida Maria Portela-Gomes, Mats Stridsberg
Jul 10, 2019·Pharmacology & Therapeutics·Marie-Christine TononJérôme Leprince
Mar 20, 2001·General and Comparative Endocrinology·L M KovalE A Lukyanetz
Apr 14, 2000·Brain Research. Molecular Brain Research·A TasiemskiM Salzet
Jan 10, 2008·Journal of Proteome Research·Steven W TaylorSoumitra S Ghosh
Dec 9, 2003·Trends in Microbiology·M H Metz-BoutigueD Aunis
Nov 17, 2004·Regulatory Peptides·Maurizio MandalàKaren B Helle
Nov 26, 2009·Regulatory Peptides·Peiman ShooshtarizadehMarie-Hélène Metz-Boutigue
Feb 2, 2010·Regulatory Peptides·Sushil K MahataDaniel T O'Connor
Mar 10, 2010·Regulatory Peptides·Guida M Portela-GomesMats Stridsberg
Oct 23, 2010·Regulatory Peptides·Sushil K MahataDaniel T O'Connor

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