Antibacterial Peptides: Opportunities for the Prevention and Treatment of Dental Caries

Probiotics and Antimicrobial Proteins
Adam Pepperney, Michael L Chikindas

Abstract

Dental caries is a multifactorial disease that is a growing and costly global health concern. The onset of disease is a consequence of an ecological imbalance within the dental plaque biofilm that favors specific acidogenic and aciduric caries pathogens, namely Streptococcus mutans and Streptococcus sobrinus. It is now recognized by the scientific and medical community that it is neither possible nor desirable to totally eliminate dental plaque. Conversely, the chemical biocides most commonly used for caries prevention and treatment indiscriminately attack all plaque microorganisms. These treatments also suffer from other drawbacks such as bad taste, irritability, and staining. Furthermore, the public demand for safe and natural personal hygiene products continues to rise. Therefore, there are opportunities that exist to develop new strategies for the treatment of this disease. As an alternative to conventional antibiotics, antibacterial peptides have been explored greatly over the last three decades for many different therapeutic uses. There are currently tens of hundreds of antibacterial peptides characterized across the evolutionary spectrum, and among these, many demonstrate physical and/or biological properties that may be...Continue Reading

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Citations

Feb 28, 2014·Future Microbiology·Timothy D ArthurMichael L Chikindas
Feb 6, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Anna Kurek-GóreckaJerzy Stojko
Sep 10, 2020·Brazilian Dental Journal·Thiago VieiraLucianne C Maia
Jul 28, 2017·Journal of Oral Microbiology·Zhejun WangMarkus Haapasalo
Dec 7, 2018·BioMed Research International·Káthia Santana MartinsFábio Alessandro Pieri
Jan 9, 2021·Archives of Oral Biology·John Yun NiuChun Hung Chu
Jan 21, 2021·International Journal of Molecular Sciences·Abid Ali KhanHans-Peter Deigner
Jan 13, 2018·Archives of Oral Biology·A M Fernández-PresasJ L Molinarí Soriano
Jun 20, 2021·Journal of Dentistry·John Yun NiuChun Hung Chu

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