Antibacterial Polyketide Heterodimers from Pyrenacantha kaurabassana Tubers

Journal of Natural Products
Leslie Boudesocque-DelayeCécile Enguehard-Gueiffier

Abstract

Two heterodimers comprising anthraquinone and methylbenzoisocoumarin moieties (1 and 2) were isolated, together with emodin and physcion from the tubers of Pyrenacantha kaurabassana. The structures of 1 and 2 were established by NMR spectroscopy, including the analysis of a 2D INADEQUATE spectrum. On the basis of the data obtained, the structures that were previously proposed in the literature for these compounds were revised. Compounds 1 and 2 showed antibacterial activity against three different strains of Staphylococcus aureus. Compound 2 also showed bactericidal activity against Helicobacter pylori.

References

Aug 1, 1973·Applied Microbiology·E B Lillehoj, M S Milburn
Oct 23, 2004·Journal of Natural Products·Dulcie A MulhollandPeter Sandor
May 17, 2011·Journal of Ethnopharmacology·Emmanuel O AweOyindamola O Abiodun

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