PMID: 2114420May 1, 1990Paper

Antibacterial polysaccharide antibody deficiency after allogeneic bone marrow transplantation

Journal of Clinical Immunology
I QuintiF Aiuti

Abstract

Allogeneic bone marrow-engrafted adults immunized with meningococcal types A and C and pneumococcal type 14 polysaccharide antigens showed only low antibody titers of the IgM class, no antibody titers of the IgG or IgA classes, and no bactericidal activity in vitro. The analytical isoelectrofocusing showed the appearance of a restricted pattern of clonotypes in a minority of subjects. These observations are consistent with the hypothesis that B cells in bone marrow transplant patients express some characteristics of neonatal B cells and suggest that polysaccharide-protein conjugates, rather than isolated polysaccharide, might be utilized in the setting of bone marrow transplantation.

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Citations

Jul 1, 1993·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·V HammarströmP Ljungman
Jan 1, 1993·The Journal of Allergy and Clinical Immunology·L A SandersB J Zegers
Apr 12, 2003·The Journal of Experimental Medicine·Stephanie KruetzmannRita Carsetti
May 1, 1995·Journal of Clinical Immunology·M A AvanziniF Locatelli
Apr 17, 2001·Infectious Disease Clinics of North America·D C Molrine, P L Hibberd
Apr 10, 2010·International Journal of Immunopathology and Pharmacology·M A AvanziniM Marconi

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