Antibacterial potential of Antarctic lichens against human pathogenic Gram-positive bacteria

Phytotherapy Research : PTR
Babita PaudelJoung Han Yim

Abstract

Extracts from five Antarctic lichens (L3, Stereocaulon alpinum; L5, Ramalina terebrata; L6, Caloplaca sp.; L8, Lecanora sp.; and L17, Caloplaca regalis) were tested for antimicrobial activities against several clinically important microbes by disk diffusion. The minimum inhibitory concentration (MIC) of each extract was determined by a broth dilution method. Extracts from L3, L5, L6 and L8 were active against two Gram(+) strains. B. subtilis was more sensitive to lichen extracts (except L5) than S. aureus. The MIC of lichen extracts against B. subtilis and S. aureus was observed from 36.7 +/- 0.3 to 953.8 +/- 85.8 microg/mL and 68.5 +/- 0.6 to >1000 microg/mL, respectively. Comparisons of MIC values of Antarctic lichen crude extracts to previously published MIC values of some reported lichen metabolites against Gram(+) bacteria indicated that Antarctic lichens might be an enriched source of effective antibacterial agents against clinically relevant Gram(+) species.

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Citations

Jun 18, 2010·Antonie van Leeuwenhoek·Nazia MojibAsim K Bej
May 17, 2013·The Journal of Antibiotics·Hari Datta BhattaraiJoung Han Yim
May 23, 2015·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Antônio Sérgio Nascimento MoreiraIvo José Curcino Vieira
May 28, 2014·Pharmaceutical Biology·Gajendra ShresthaLarry L St Clair
Feb 16, 2015·Cytotechnology·Marijana KosanićOlivera Milošević-Djordjević
Apr 5, 2012·Pharmaceutical Biology·Vasudeo P Zambare, Lew P Christopher
Nov 3, 2017·Chemical Society Reviews·Mark J CalcottJeremy G Owen
Jan 18, 2020·Biomolecules·Zuzana SolárováPeter Solár
Mar 1, 2017·Marine Drugs·Yuan TianFeng-Chun Zhao
Jun 15, 2021·Evidence-based Complementary and Alternative Medicine : ECAM·Polwatta Samaraweera Arachchige Ishara ShiromiDakshika Wanniarachchi

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