Antibacterial Potential of Secondary Metabolites from Indonesian Marine Bacterial Symbionts

International Journal of Microbiology
Risa NofianiTaifo Mahmud

Abstract

Indonesian marine environments are known to house diverse organisms. However, the potential for bacteria from these environments as a source of antibacterial agents has not been widely studied. This study aims to explore the antibacterial potential of secondary metabolites produced by bacterial symbionts from sponges and corals collected in the Indonesian waters. Extracts of 12 bacterial isolates from sponges or corals were prepared by cultivating the bacteria under a number of different media conditions and using agar well diffusion assays to test for antibacterial activity. In addition, the morphology, physiology, and biochemical characteristics and 16S rRNA sequence of each isolate were used to determine their taxonomic classification. All tested bacterial isolates were able to produce secondary metabolites with various levels of antibacterial activity depending on medium composition and culture conditions. Two of the bacteria (RS3 and RC4) showed strong antibacterial activities against both Gram-negative and Gram-positive bacteria. A number of isolates (RS1, RS3, and RC2) were co-cultured with mycolic acid-containing bacteria, Mycobacterium smegmatis or Rhodococcus sp. However, no improvements in their antibacterial activit...Continue Reading

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Citations

Nov 20, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Roberto Pestana-NoblesJuvenal Yosa

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Datasets Mentioned

BETA
MT011999
MT012001
MT012002
MT012003
MT012004
MT012006
MT012007
MT448898

Methods Mentioned

BETA
PCR

Software Mentioned

Clustal Omega webserver
BLASTN
INS
GNPS
FigTree
MassHunter Qualitative Analysis
MGF
MassHunter
MzData

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