Antibacterial properties and atomic resolution X-ray complex crystal structure of a ruthenocene conjugated β-lactam antibiotic

Chemical Communications : Chem Comm
Eric M LewandowskiYu Chen

Abstract

We have determined a 1.18 Å resolution X-ray crystal structure of a novel ruthenocenyle-6-aminopenicillinic acid in complex with CTX-M β-lactamase, showing unprecedented details of interactions between ruthenocene and protein. As the first product complex with an intact catalytic serine, the structure also offers insights into β-lactamase catalysis and inhibitor design.

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Citations

Jul 18, 2017·Dalton Transactions : an International Journal of Inorganic Chemistry·Tameryn StringerGregory S Smith
Feb 8, 2019·Chemistry : a European Journal·Miguel A SierraMaría C de la Torre
Jun 5, 2019·Experimental Biology and Medicine·Ben A Shurina, Richard C Page
Dec 19, 2019·Dalton Transactions : an International Journal of Inorganic Chemistry·Łukasz SzczupakKonrad Kowalski
Mar 18, 2020·Chembiochem : a European Journal of Chemical Biology·Eric M LewandowskiKonrad Kowalski
Feb 27, 2021·Bioorganic & Medicinal Chemistry Letters·Mathieu MichautGaëtan L A Mislin
Jul 13, 2021·Biological Chemistry·Jeannine Hess
Apr 4, 2019·ACS Infectious Diseases·Nicholas J TorelliYu Chen

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