Antibacterial protection of suture material by chlorhexidine-functionalized polyelectrolyte multilayer films.

Journal of Materials Science. Materials in Medicine
Jean-Claude HarnetConstant Vodouhê

Abstract

The formation of bacterial biofilms on the surface of implanted materials is a critical factor that may lead to chronic microbial infection and tissue necrosis. In the present study we analysed the stability of polyelectrolyte multilayer (ML) films on suture materials and the antibacterial effect obtained with chlorhexidine (CHX)-functionalized films built on different types of suture materials such as silk, polyester and copolymer of glycolide and L: -lactide. The comparison of Escherichia coli culture on glass coverslips and glass coverslips with ML and CHX showed at 24 h an inhibition of the bacterial relative luminescence (40.68%, P < 0.5) and at 48 h (99.46%, P < 0.001). In another way, simple soaking of suture material overnight in CHX digluconate 20% without polyelectrolyte films did not at all protect sutures from bacterial colonization but CHX-functionalized polyelectrolyte films, made from poly-L: -glutamic acid and poly-L: -lysine, inhibited Escherichia coli proliferation.

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Citations

Jul 7, 2014·Journal of Materials Science. Materials in Medicine·S De SimoneM Pollini
May 23, 2012·Journal of Controlled Release : Official Journal of the Controlled Release Society·Christopher B WeldonDaniel S Kohane
Oct 30, 2015·Langmuir : the ACS Journal of Surfaces and Colloids·Lydie SeonFouzia Boulmedais
Jul 31, 2012·Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology·Fernando CruzMauro Cruz
Jan 14, 2021·Biomedical Physics & Engineering Express·Md Lukman HakimShazid Md Sharker
Apr 9, 2021·Journal of Biomedical Materials Research. Part a·Xiaoxuan DengAzam Ali

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