Abstract
Two new pregnane-type steroidal alkaloids, saligcinnamide [(20S,2'E)-20-(N,N-dimethylamino)-3beta-(3'-phenyl-2'-propenyl-N-meth ylamido)pregnane](1) and N(a)-methyl epipachysamine-D [(20S)-20-(N,N-dimethylamino)-3beta-(N-methylbenzamido)pregnane](2 ), along with a known base, epipachysamine D [(20S)-20-(N,N-dimethylamino)-3beta-(benzamido)pregnane] (3), were isolated from the EtOH extracts of the roots and stems of Sarcococca saligna. The new bases exhibited antibacterial activity against several human pathogenic bacteria. Two derivatives of 1, dihydrosaligcinnarnide [(20S)-20-(N,N-dimethylamino)-3beta-(3'-phenylpropionoyl-N-meth ylamido)pregnane](4) and dihydrosaligcinnamine [(20S)-20-(N,N-dimethylamino)-3beta-N-(3'-phenylpropyl-N-methylamino)pre gnane](5), and a derivative of 2, N(a)-methyl epipachysamine [(20S)-20-(N,N-dimethylamino)-3beta-(N-benzyl,N-methylamino)pregnane](6) were prepared and their antibacterial activity determined.
Citations
Dec 7, 2006·Archives of Pharmacal Research·Muhammad Nabeel Ghayur, Anwarul Hassan Gilani
Aug 18, 2009·Applied Biochemistry and Biotechnology·Kamyar Mollazadeh MoghaddamAhmad Reza Shahverdi
Mar 24, 2005·Steroids·M Iqbal Choudhary Atta-ur-Rahman
Sep 13, 2011·Journal of Medicinal Chemistry·Lamia Djouhri-BouktabJean Michel Brunel
May 24, 2008·Natural Product Reports·Krishna P DevkotaNorbert Sewald
Apr 15, 2010·Journal of Asian Natural Products Research·Kang He, Jiang Du
Feb 23, 2002·Natural Product Letters·U L JayasingheA Weerasooriya
May 5, 2007·Natural Product Research·Krishna P DevkotaNorbert Sewald
Mar 12, 2013·Natural Product Research·Muhammad Iqbal Choudhary
Nov 7, 2002·Chemical & Pharmaceutical Bulletin·Surya K KalauniMohan Bikram Gewali
Sep 11, 2007·Chemical & Pharmaceutical Bulletin·Krishna Prasad DevkotaNorbert Sewald
May 9, 2014·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Takayuki TohgeAlisdair R Fernie
Aug 10, 2007·Expert Opinion on Investigational Drugs·Chanaz Salmi, Jean M Brunel
Dec 4, 2012·Fitoterapia·M Iqbal Choudhary
Nov 19, 2011·Steroids·Syed Ghulam Musharraf Atta-ur-Rahman
Mar 26, 2011·Bioorganic & Medicinal Chemistry Letters·Manmeet KumarRakesh Maurya
Mar 31, 2015·Medicinal Research Reviews·Qi-Wei JiangZhi Shi
Aug 3, 2013·Chemical Biology & Drug Design·Dominique BrossardLaïla El Kihel
Feb 3, 2005·Steroids· Atta-ur-RahmanM Iqbal Choudhary
Jun 21, 2015·International Immunopharmacology·Hamid AliNurul Kabir
Nov 6, 2018·International Journal of Cancer. Journal International Du Cancer·Prasanta DeyHyung Sik Kim
Mar 25, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Agnieszka WojtkielewiczJacek W Morzycki
Dec 24, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Shaojie HuoJiang Du
Aug 7, 2008·Journal of Natural Products·Krishna P DevkotaNorbert Sewald
Jan 13, 2009·Journal of Natural Products·Yu-Xin YanMing-Hua Qiu