Antibacterial strategies inspired by the oxidative stress and response networks

The Journal of Microbiology
So Youn KimYou-Hee Cho

Abstract

Oxidative stress arises from an imbalance between the excessive accumulation of reactive oxygen species (ROS) and a cell's capability to readily detoxify them. Although ROS are spontaneously generated during the normal oxygen respiration and metabolism, the ROS generation is usually augmented by redox-cycling agents, membrane disrupters, and bactericidal antibiotics, which contributes their antimicrobial bioactivity. It is noted that all the bacteria deploy an arsenal of inducible antioxidant defense systems to cope with the devastating effect exerted by the oxidative stress: these systems include the antioxidant effectors such as catalases and the master regulators such as OxyR. The oxidative stress response is not essential for normal growth, but critical to survive the oxidative stress conditions that the bacterial pathogens may encounter due to the host immune response and/or the antibiotic treatment. Based on these, we here define the ROS-inspired antibacterial strategies to enhance the oxidative stress of ROS generation and/or to compromise the bacterial response of ROS detoxification, by delineating the ROSgenerating antimicrobials and the core concept of the bacterial response against the oxidative stress.

References

Apr 1, 1976·Chemico-biological Interactions·M Tomasz
Jun 1, 1992·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·E D Harris
May 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·M F ChristmanB N Ames
Jan 1, 1986·Annual Review of Physiology·W A Pryor
Jul 1, 1988·Urology·B A Cunha
Oct 10, 1995·Proceedings of the National Academy of Sciences of the United States of America·C GuilhotJ Beckwith
Jan 9, 1999·Clinical Microbiology Reviews·G McDonnell, A D Russell
May 26, 1999·Proceedings of the National Academy of Sciences of the United States of America·F AslundG Storz
Nov 22, 2001·Journal of Bacteriology·L C Seaver, J A Imlay
May 23, 2002·Cell·Sung Oog KimJonathan S Stamler
May 30, 2002·Biological & Pharmaceutical Bulletin·Kenroh SasakiFumihiko Yoshizaki
Sep 19, 2003·Antioxidants & Redox Signaling·Katrin Linke, Ursula Jakob
May 28, 2004·Journal of Medicinal Chemistry·Paul M O'Neill, Gary H Posner
Jul 21, 2005·Proceedings of the National Academy of Sciences of the United States of America·Valsala HaridasJordan U Gutterman
Aug 30, 2005·Antimicrobial Agents and Chemotherapy·Vincent H TamRussell E Lewis
Mar 11, 2006·Archives of Pharmacal Research·Bok Hee KimYongseog Chung
Mar 14, 2007·Molecular Systems Biology·Daniel J DwyerJames J Collins
Apr 14, 2007·Proceedings of the National Academy of Sciences of the United States of America·Tim MaischWolfgang Bäumler
Sep 7, 2007·Cell·Michael A KohanskiJames J Collins
Jan 5, 2008·Annual Review of Biochemistry·James A Imlay
Jan 16, 2010·Journal of Microbiology and Biotechnology·Seol-Hee KimYou-Hee Cho
Sep 24, 2011·Advances in Pharmacological Sciences·Varsha ShuklaHarish C Pant
Jan 26, 2012·Nucleic Acids Research·Qing WeiPierre Cornelis
Aug 22, 2012·Antimicrobial Agents and Chemotherapy·Timothy R SampsonDavid S Weiss
Jan 8, 2013·Nature Biotechnology·Mark P BrynildsenJames J Collins
May 7, 2013·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Amelia E BarberMatthew A Mulvey
Jul 5, 2013·Science Translational Medicine·Sameer KalghatgiJames J Collins
Jul 19, 2013·The Journal of Biological Chemistry·Claudia M Cremers, Ursula Jakob
Aug 21, 2013·Antimicrobial Agents and Chemotherapy·Patrick M SchlievertJohn R Kirby
Jan 25, 2014·FEMS Microbiology Letters·Mingxuan LiMingqiang Qiao

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Citations

Feb 27, 2019·The Journal of Microbiology·Joon-Hee Lee
Aug 4, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Maria Barbara PisanoMaria João Matos
Jul 1, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Siti Nurhanna RiduanYugen Zhang
Jul 19, 2020·Experimental Dermatology·Pierre-Jean RacineMarc G J Feuilloley
Sep 16, 2020·Antioxidants·Helmut Sies
Jan 31, 2021·Biotechnology Advances·Miroslav PátekJan Nešvera
Nov 18, 2020·Biochemistry. Biokhimii︠a︡·S M VostrikovaV G Gogvadze
Dec 31, 2020·Proceedings of the National Academy of Sciences of the United States of America·Megumi InomataJohn M Leong
Feb 20, 2020·Biochemistry·Kuan-Yi Lu, Emily R Derbyshire
Mar 10, 2021·ACS Applied Materials & Interfaces·Yifan LiuJianfeng Liu
Apr 6, 2021·Frontiers in Microbiology·Fang YuanGuohui Pan
Aug 28, 2021·Evidence-based Complementary and Alternative Medicine : ECAM·Najwan JubairAyesha Fatima

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