Antibacterial Synergy of Silver Nanoparticles with Gentamicin and Chloramphenicol against Enterococcus faecalis

Pharmacognosy Magazine
Sagar KatvaSanket Kaushik

Abstract

Enterococcus faecalis (Ef) is a multidrug-resistant pathogenic bacteria associated with hospital-acquired infections. Ef is involved in a number of infectious diseases. It generally infects patients with the weekend immune system, i.e. a person mostly acquires Ef infections in the hospital, especially in intensive care units and thus, is more likely to be resistant to many antibiotics. Development of resistance against various antibiotics and emergence of drug-resistant strains is a growing global concern. Due to the unselective use of antibiotics for a long time multidrug resistant bacteria and extensively drug-resistant, which is now posing a new challenge to the medical community. To treat infections caused by Ef, the synergistic effect of different antibiotics with silver nanoparticles (AgNPs) was tested against Ef. In the present study, synthesis of AgNPs was carried out from the cell-free supernatant of Klebsiella pneumoniae. AgNPs were characterized using various techniques, namely, ultraviolet-visible spectrophotometry, transmission electron microscopy, and Fourier transform infrared spectroscopy. Moreover, process optimization was done for enhanced production of AgNPs. In addition, antimicrobial activity of the nanopar...Continue Reading

Citations

Jan 24, 2019·International Journal of Molecular Sciences·Chengzhu LiaoSie Chin Tjong
Jul 23, 2020·BioMed Research International·Moad KhalifaWei Cun See Too
Jul 18, 2018·Frontiers in Microbiology·Pedro V BaptistaAlexandra R Fernandes
Oct 10, 2020·Scientific Reports·Mona A AlqahtaniAfrah E Mohammed
May 4, 2021·Frontiers in Microbiology·Oliver McNeillyCindy Gunawan
Jun 25, 2021·Environmental Science and Pollution Research International·Hasnaa E-B GhonamKhouloud M Barakat
Apr 30, 2019·ACS Nano·Danielle S W BenoitDavid Fraser

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Methods Mentioned

BETA
transmission electron microscopy
infrared spectroscopy
surface plasmon resonance

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