PMID: 9181477May 1, 1997Paper

Antibacterial vaccines: impact of antigen handling and immune response

Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte
S H Kaufmann

Abstract

The emerging awareness that diseases caused by bacterial pathogens cannot be vanquished by chemotherapy alone has recalled interest in the generation of novel vaccines. Vaccines have proven their efficacy for the bacterial pathogens that are controlled by antibodies. In contrast, satisfactory vaccines are not available for intracellular bacteria that are under the control of T lymphocytes. This review describes the T cell populations that must be activated by successful vaccines against intracellular bacteria and discusses parameters that need to be fulfilled by protective T cell antigens. These parameters include: (a) the intracellular localization of the pathogen with major effect on antigen presentation and stimulation of distinct T cell subsets and (b) the antigen display which markedly influences kinetics of T cell activation. Using tuberculosis as an example, the advantages and disadvantages of second-generation vaccine candidates are discussed.

Citations

Jun 2, 2011·Proceedings of the National Academy of Sciences of the United States of America·Oretta FincoRenata Grifantini
Jan 15, 2007·Pakistan Journal of Biological Sciences : PJBS·K A Abd el-RazikW M Ahmed
Jul 21, 2001·Tuberculosis·J M PollockS D Neill
Dec 18, 2004·The Journal of Infection·Salih CesurUgur Ciftci

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