Antibiofilm and Antivirulence Properties of Indoles Against Serratia marcescens

Frontiers in Microbiology
Sivasamy SethupathyJintae Lee

Abstract

Indole and its derivatives have been shown to interfere with the quorum sensing (QS) systems of a wide range of bacterial pathogens. While indole has been previously shown to inhibit QS in Serratia marcescens, the effects of various indole derivatives on QS, biofilm formation, and virulence of S. marcescens remain unexplored. Hence, in the present study, we investigated the effects of 51 indole derivatives on S. marcescens biofilm formation, QS, and virulence factor production. The results obtained revealed that several indole derivatives (3-indoleacetonitrile, 5-fluoroindole, 6-fluoroindole, 7-fluoroindole, 7-methylindole, 7-nitroindole, 5-iodoindole, 5-fluoro-2-methylindole, 2-methylindole-3-carboxaldehyde, and 5-methylindole) dose-dependently interfered with quorum sensing (QS) and suppressed prodigiosin production, biofilm formation, swimming motility, and swarming motility. Further assays showed 6-fluoroindole and 7-methylindole suppressed fimbria-mediated yeast agglutination, extracellular polymeric substance production, and secretions of virulence factors (e.g., proteases and lipases). QS assays on Chromobacterium violaceum CV026 confirmed that indole derivatives interfered with QS. The current results demonstrate the an...Continue Reading

References

Jan 1, 1997·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·J F Acar, F W Goldstein
Oct 16, 1999·FEMS Microbiology Letters·K Kawamura-SatoM Ohta
Jul 21, 2001·Lancet·P S Stewart, J W Costerton
Sep 7, 2001·Annual Review of Microbiology·M B Miller, B L Bassler
Aug 28, 2002·International Journal of Medical Microbiology : IJMM·Philip S Stewart
Nov 17, 2006·Nature Reviews. Microbiology·Neil R WilliamsonGeorge P C Salmond
Apr 27, 2007·FEMS Microbiology Reviews·Rob Van HoudtChris W Michiels
May 8, 2007·Applied and Environmental Microbiology·Jintae LeeThomas K Wood
Aug 7, 2007·Journal of Bacteriology·Robert M Q ShanksGerard J Nau
May 28, 2008·International Journal of Food Microbiology·Basavaraj GirennavarBhimanagouda S Patil
Jul 8, 2008·The Journal of Hospital Infection·D IvanovaA Bauernfeind
Mar 24, 2009·Analytical Biochemistry·M Amin-ul MannanK Ganesan
Jan 15, 2010·FEMS Microbiology Reviews·Jin-Hyung Lee, Jintae Lee
Feb 13, 2010·International Journal of Antimicrobial Agents·Niels HøibyOana Ciofu
Jul 6, 2010·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Ronald N Jones
Aug 10, 2010·Nature Reviews. Microbiology·Daniel B Kearns
Sep 3, 2010·Nature·Henry H LeeJames J Collins
Jan 1, 2009·Microbial Biotechnology·Jintae LeeThomas K Wood
Mar 23, 2011·Antimicrobial Agents and Chemotherapy·Gilles BrackmanTom Coenye
May 31, 2011·BMC Microbiology·Yong-Guy KimJintae Lee
Jan 19, 2012·FEMS Microbiology Letters·Jin-Hyung LeeJintae Lee
Nov 13, 2012·Biotechnology Advances·Vipin Chandra Kalia
Nov 13, 2012·PloS One·Elena B M BreidensteinRobert E W Hancock
Jan 16, 2013·Applied Microbiology and Biotechnology·Jin-Hyung LeeJintae Lee
Mar 9, 2013·Microbiology and Molecular Biology Reviews : MMBR·Breah LaSarre, Michael J Federle
Nov 8, 2013·Proceedings of the National Academy of Sciences of the United States of America·Jessica M A BlairLaura J V Piddock
Nov 20, 2014·Organic & Biomolecular Chemistry·Nripendra Nath BiswasNaresh Kumar
Dec 17, 2014·International Journal of Food Microbiology·Yong-Guy KimJintae Lee
Feb 13, 2015·Applied Microbiology and Biotechnology·José A Gutiérrez-BarranqueroFergal O'Gara

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Citations

Jul 24, 2021·Journal of Applied Microbiology·Shanshan ZhangTom Defoirdt
Aug 20, 2021·Frontiers in Microbiology·Ezhaveni SathiyamoorthiJintae Lee
Aug 28, 2021·Applied Biochemistry and Biotechnology·Jyoti VishwakarmaSirisha L Vavilala

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Methods Mentioned

BETA
environmental stress
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biosensor

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