Antibiotherapy of severe ENT infections in children: propositions of the French Group of Pediatric Infectious Diseases (PID) of the French Society of Pediatrics

Archives de pédiatrie : organe officiel de la Sociéte française de pédiatrie
E GrimprelR Cohen

Abstract

The French Group of Pediatric Infectious Diseases (PID) of the French Society of Pediatrics found necessary to issue in 2011 therapeutic proposals concerning antibiotic treatment in severe ENT infections in children (acute mastoiditis, severe sinusitis, peripharyngeal abscess). They took into account, for each clinical situation, published studies and existing guidelines, the most frequently encountered bacterial species, their usual sensitivity to antibiotics, their pharmacokinetic and pharmacodynamic (PK-PD) characteristics. These propositions aim to ensure the proper use of antibiotics and to limit the development of bacterial resistance to antibiotics by minimizing the use of broadspectrum molecules, especially cephalosporins and penems. These infections are often multi microbial and respond to aerobic flora similar to that found in non severe community acquired ENT infections and soft tissue infections ( Streptococcus pyogenes or group A Streptococcus(GAS), Streptococcus pneumoniae, Staphylococcus aureus and Haemophilus influenzae). Anaerobic flora may be associated and implicated in some situations. In most cases, high-dosage of amoxicillin +/- clavulanic acid offers the best PK/PD profile and allows to avoid the overuse ...Continue Reading

References

Feb 10, 1998·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·W A Craig
Nov 14, 2003·The Pediatric Infectious Disease Journal·John S BradleyGeorge L Drusano
Nov 13, 2008·Archives de pédiatrie : organe officiel de la Sociéte française de pédiatrie·E GrimprelUNKNOWN Paediatric Infectious Diseases Group of the French Society of Paediatricis (GPIP)
Mar 15, 2011·Archives de pédiatrie : organe officiel de la Sociéte française de pédiatrie·R CohenD Gendrel
Dec 24, 2013·Archives de pédiatrie : organe officiel de la Sociéte française de pédiatrie·M LorrotE Grimprel
Dec 24, 2013·Archives de pédiatrie : organe officiel de la Sociéte française de pédiatrie·V HentgenE Grimprel
Dec 24, 2013·Archives de pédiatrie : organe officiel de la Sociéte française de pédiatrie·H HaasE Grimprel

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Citations

Sep 11, 2014·BMC Ear, Nose, and Throat Disorders·Emilie GeorgetFouad Madhi
Jan 6, 2016·Archives of Disease in Childhood·A Berthe-AucejoS Prot-Labarthe

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