Antibiotic Allergy in Children: More than Just a Label

International Archives of Allergy and Immunology
Elissa M AbramsMoshe Ben-Shoshan

Abstract

Within the broad category of adverse drug reactions in children, there has been a recent focus specifically on the evaluation of children with antibiotic allergy, in particular, beta-lactam allergy. The potential consequences of being labeled beta-lactam allergy are increasingly recognized. Appropriate evaluation of children with suspected reactions to antibiotics is essential as it is increasingly being recognized that the label of "penicillin allergy" is associated with adverse health and economic outcomes. This review will focus on the 3 main classes of antibiotics reported to cause allergic reactions in children: beta lactams (penicillin derivatives and cephalosporins), macrolides, and sulfonamides. This article is a narrative review of the prevalence, diagnosis, and management of different types of antibiotic allergies in children. Our review reveals that antibiotic allergy is often overreported and not appropriately diagnosed in the pediatric age groups. There is a recent shift in the diagnostic paradigm from the use of skin tests and if negative challenges to the use of challenge only in the pediatric age group. Larger studies to establish the usefulness and safety of this new approach as well as updated guidelines are n...Continue Reading

References

Aug 1, 1987·Annals of Internal Medicine·A SaxonD C Adelman
Aug 1, 1981·Clinical Pharmacology and Therapeutics·C A NaranjoD J Greenblatt
May 18, 1999·The Journal of Allergy and Clinical Immunology·M BlancaC Juarez
Oct 3, 1999·Pediatrics·C PonvertJ Paupe
Oct 27, 1999·Gastroenterology·M L HautekeeteA P Geubel
Feb 8, 2006·The Journal of Allergy and Clinical Immunology·Hoai-Bich Co MinhPascal Demoly
Jul 27, 2007·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Fazil OrhanYusuf Gedik
Nov 22, 2007·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·E Rebelo GomesP Demoly
Jan 29, 2008·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·L LangeE Rietschel
Mar 12, 2008·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·N AbuafR Girot
Jan 13, 2009·Allergy·M BlancaM Atanasković-Marković
Jul 1, 2009·Immunology and Allergy Clinics of North America·Oliver V HausmannDidier G Ebo
Mar 5, 2010·The Journal of Allergy and Clinical Immunology·David A Khan, Roland Solensky
Mar 5, 2010·The Journal of Allergy and Clinical Immunology·F Estelle R Simons
May 22, 2010·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Francesca MoriElio Novembre
Jul 9, 2010·The Medical Clinics of North America·Benno Schnyder
Aug 27, 2010·Science Translational Medicine·Damien PicardPhilippe Musette
Sep 16, 2010·British Journal of Clinical Pharmacology·Lise AagaardEbba Holme Hansen
Oct 12, 2010·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·UNKNOWN Joint Task Force on Practice ParametersUNKNOWN Joint Council of Allergy, Asthma and Immunology
Jul 29, 2011·Pediatric Dermatology·Lesley StarnesRobert B Skinner
May 23, 2012·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Asia N RashedAntje Neubert
Jun 29, 2012·The New England Journal of Medicine·Robert S Stern
Jun 30, 2012·Current Opinion in Allergy and Clinical Immunology·F Estelle R SimonsUNKNOWN World Allergy Organization
Nov 10, 2012·The British Journal of Dermatology·A BarbaudUNKNOWN Toxidermies group of the French Society of Dermatology
Jun 1, 2008·The World Allergy Organization Journal·Werner J Pichler
Apr 5, 2013·Journal of Hospital Medicine : an Official Publication of the Society of Hospital Medicine·Ramzy H RimawiDawd S Siraj
Nov 6, 2013·The Journal of Allergy and Clinical Immunology·Eric Macy, Richard Contreras
Feb 21, 2014·Dermatologic Therapy·Anubhav N Mathur, Erin F Mathes
Feb 26, 2014·The Journal of Allergy and Clinical Immunology. in Practice·Eric Macy, Eunis W Ngor
Feb 26, 2014·The Journal of Allergy and Clinical Immunology. in Practice·Antonino Romano, Jean-Christoph Caubet
Apr 23, 2014·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Ceren CanMehtap Yazicioglu
May 23, 2014·Current Opinion in Allergy and Clinical Immunology·Tahia D FernandezMaria J Torres
Sep 5, 2014·BMJ : British Medical Journal·Katharina DworzynskiUNKNOWN National Institute for Health and Care Excellence
Sep 30, 2014·The Journal of Allergy and Clinical Immunology·Eric Macy, Richard Contreras
Nov 12, 2014·Annual Review of Medicine·Rebecca PavlosElizabeth Phillips
Jan 7, 2015·Journal of Burn Care & Research : Official Publication of the American Burn Association·Anna BeckMichael J Mosier
Jan 23, 2015·The Journal of Allergy and Clinical Immunology. in Practice·Francesca MoriElio Novembre
Jan 28, 2015·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·R MirakianUNKNOWN Standards of Care Committee of the British Society for Allergy and Clinical Immunology
Mar 31, 2015·International Journal of Clinical Pharmacy·Tugba ArikogluSemanur Kuyucu
Jun 19, 2015·Pharmacogenetics and Genomics·Thachanan KongpanWichittra Tassaneeyakul
Jul 17, 2015·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·S BarniE Novembre

❮ Previous
Next ❯

Citations

Jul 11, 2020·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·Jennifer Lisa Penner ProtudjerElissa Michele Abrams
Apr 23, 2020·International Journal of Environmental Research and Public Health·Iwona Poziomkowska-Gęsicka, Michał Kurek
Nov 13, 2020·British Journal of Clinical Pharmacology·Haifa Ben RomdhaneKarim Aouam
Sep 9, 2020·The Journal of Allergy and Clinical Immunology. in Practice·Luca Delli ColliMoshe Ben-Shoshan
Jan 28, 2021·Environmental Science and Pollution Research International·Xinji LiuFangbiao Tao
Feb 24, 2021·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Sophia Tsabouri, Marina Atanaskovic-Markovic
May 28, 2021·The Pediatric Infectious Disease Journal·Dagmar BerghuisMark G J de Boer
May 17, 2021·Current Opinion in Allergy and Clinical Immunology·Marina Atanaskovic-Markovic, Sophia Tsabouri
Nov 7, 2019·International Archives of Allergy and Immunology·Dagmar Simon

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anaphylaxis

Anaphylaxis is a serious allergic reaction that is rapid in onset and may cause death.

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.