Antibiotic dosing adjustments in patients with declined kidney function at a tertiary hospital in Jordan.

International Journal of Clinical Practice
Fadi JarabOsama Y Alshogran

Abstract

Estimating kidney function is essential to consider in drug dosing for renally eliminated drugs. It has been estimated that more than half of medications' adverse effects are caused by the inappropriate dosing. Limited data are available on drug dosing adjustment, particularly the antibiotics, among Jordanian patients with declined kidney function. The aim of this study was to evaluate the extent of antibiotics' dose adjustment according to the recent guidelines of drugs' renal dose adjustment. The present study utilised data from a previous retrospective study, which recruited inpatients who were clinically stable and received IV antibiotics for more than 24 hours at King Abdullah University Hospital. Sociodemographic and clinical data were collected by referring to information technology departments at KAUH. The percentage of antibiotics which were inappropriately adjusted based on creatinine clearance was evaluated using Lexicomp-Clinical Drug information website. A total of 110 antibiotics were dispensed for 80 patients. Results showed that (36.25%) of patients were given antibiotics without renal dose adjustments based on their creatinine clearance. Urinary tract infections followed by respiratory tract infections were the...Continue Reading

References

Nov 1, 1992·The Annals of Pharmacotherapy·T B VreeP G Anderson
Nov 1, 1983·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·W M BennettI Singer
Jun 26, 2001·Journal of General Internal Medicine·A D FalconnierM Martin-Facklam
Sep 25, 2003·Archives of Internal Medicine·Suzan N KucukarslanDaniel A Nafziger
Apr 1, 2004·The Annals of Pharmacotherapy·Charron L LongDavid J Magid
Apr 27, 2005·American Journal of Medical Quality : the Official Journal of the American College of Medical Quality·Ira S NashMark R Chassin
Jun 29, 2006·The Annals of Pharmacotherapy·Elisabeth A van DijkPeter A G M De Smet
Nov 8, 2007·JAMA : the Journal of the American Medical Association·Josef CoreshAndrew S Levey
Nov 13, 2010·Indian Journal of Nephrology·S Nayak-Rao
Oct 29, 2011·Mayo Clinic Proceedings·Shira Doron, Lisa E Davidson
Jun 28, 2013·British Journal of Clinical Pharmacology·Euan A SandilandsDavid J Webb
Nov 6, 2013·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Alexandra FaragArsh K Jain
Dec 24, 2013·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Allan J CollinsLawrence Agodoa
Sep 9, 2017·Journal of Renal Care·Amani A KhalilAyman Hamdan Mansour
Sep 12, 2018·Saudi Pharmaceutical Journal : SPJ : the Official Publication of the Saudi Pharmaceutical Society·Anan S JarabRana Abu Farha

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