Antibiotic growth promoters virginiamycin and bacitracin methylene disalicylate alter the chicken intestinal metabolome.

Scientific Reports
U GaddeE P Lillehoj

Abstract

Although dietary antibiotic growth promoters have long been used to increase growth performance in commercial food animal production, the biochemical details associated with these effects remain poorly defined. A metabolomics approach was used to characterize and identify the biochemical compounds present in the intestine of broiler chickens fed a standard, unsupplemented diet or a diet supplemented with the antibiotic growth promoters, virginiamycin or bacitracin methylene disalicylate. Compared with unsupplemented controls, the levels of 218 biochemicals were altered (156 increased, 62 decreased) in chickens given the virginiamycin-supplemented diet, while 119 were altered (96 increased, 23 decreased) with the bacitracin-supplemented diet. When compared between antibiotic-supplemented groups, 79 chemicals were altered (43 increased, 36 decreased) in virginiamycin- vs. bacitracin-supplemented chickens. The changes in the levels of intestinal biochemicals provided a distinctive biochemical signature unique to each antibiotic-supplemented group. These biochemical signatures were characterized by increases in the levels of metabolites of amino acids (e.g. 5-hydroxylysine, 2-aminoadipate, 5-hydroxyindoleaceate, 7-hydroxyindole sul...Continue Reading

References

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Citations

Sep 24, 2019·Poultry Science·Katia Maria CardinalAndréa Machado Leal Ribeiro
Jun 11, 2019·Frontiers in Microbiology·Juan Manuel Peralta-SánchezManuel Martínez-Bueno
Apr 9, 2020·Frontiers in Veterinary Science·Inkyung ParkHyun S Lillehoj
Mar 12, 2021·Animal Bioscience·Keesun YuCheol-Heui Yun
Jun 3, 2021·Animals : an Open Access Journal From MDPI·Katarzyna KrysiakMariusz Korczyński
Aug 8, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Muhanna Mohammed Al-ShaibaniNoraziah Mohamad Zin

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Methods Mentioned

BETA
metabolomic profiling

Software Mentioned

R
Array
JMP
Studio
Array Studio

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