Antibiotic-induced release of endotoxin: in-vitro comparison of meropenem and other antibiotics

The Journal of Antimicrobial Chemotherapy
M TrautmannR Marre

Abstract

The influence of meropenem, a new carbapenem antibiotic, on cell morphology and in-vitro lipopolysaccharide (LPS) release from Escherichia coli was compared with that of imipenem, ceftazidime, tobramycin and ciprofloxacin. Free and cell-associated LPS was quantified by means of a capture ELISA method based on the recognition of E. coli LPS by monoclonal antibodies. Microscopically, meropenem was found to induce spheroplast formation similar to that seen with imipenem, while ceftazidime and ciprofloxacin induced filament formation. Free and cell-associated LPS levels were low in the presence of meropenem, imipenem, ciprofloxacin and tobramycin, but high in the presence of ceftazidime. Reduced endotoxin release appears to be a common property of carbapenem antibiotics. Morphological changes in bacteria in the presence of antibiotics do not predict their LPS-liberating effect since ciprofloxacin induced low levels of LPS despite causing filament formation.

Citations

Jan 21, 2000·Journal of Controlled Release : Official Journal of the Controlled Release Society·I A RojasD W Grainger
Jul 27, 1999·International Journal of Antimicrobial Agents·P Periti, T Mazzei
Mar 16, 2001·Expert Opinion on Pharmacotherapy·P Periti
Jan 24, 2016·Biochimica Et Biophysica Acta·Klaus BrandenburgKarl Lohner
Sep 21, 2006·The Veterinary Clinics of North America. Small Animal Practice·Dawn Merton Boothe
Mar 10, 2011·Annals of Neurology·Gauthier LoronOlivier Baud
Jul 11, 2006·Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy·Shin KawaiShigeru Kamiya
Nov 20, 1998·Journal of Chemotherapy·I M Gould
Apr 9, 2002·Journal of Chemotherapy·R G Holzheimer
Aug 28, 1999·Journal of Chemotherapy·M TrautmannM Schneider
Jan 30, 2007·Expert Opinion on Pharmacotherapy·Ioannis P KioumisDavid P Nicolau
Jun 20, 2000·Hospital Medicine·R Stephens, C Hamilton-Davies
Aug 19, 2007·American Journal of Physiology. Renal Physiology·Richard A ZagerAdam Geballe
Feb 11, 2016·The Journal of Veterinary Medical Science·Yasunori ShinozukaKazuhiro Kawai
Sep 8, 2019·International Journal of Molecular Sciences·Kayle Dickson, Christian Lehmann

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