Antibiotic Irrigation of Pocket for Implant-Based Breast Augmentation to Prevent Capsular Contracture: A Systematic Review

Plastic Surgery
Osama A SamargandiJason Williams

Abstract

In vitro and in vivo studies have described a number of different antibiotic solutions for irrigation of the pocket in implant-based breast augmentation in an attempt to prevent the formation of capsular contracture (CC). Our objective was to evaluate the evidence that antibiotic irrigation reduced the rate of CC. A systematic search of MEDLINE, EMBASE, and CENTRAL was conducted from inception to January 2016. We included studies which examined the use of intraoperative antibiotic irrigation in women undergoing primary breast augmentation. Our primary outcome was the rate of CC. Included studies were assessed for methodological quality using validated tools. Seven studies were included in the final analysis: 1 randomized controlled trial (RCT) and 6 non-randomized studies. The mean follow-up ranged from 14 to 72 months. The rate of CC was less than 2% in 8 studies, between 3% and 6% in 4 studies, and 13.9% in 1 study. Included studies demonstrated significant clinical and methodological heterogeneity. The solitary low-quality RCT concluded that antibiotic irrigation was superior to saline irrigation. Three non-randomized studies demonstrated no significant difference in the rate of CC with the use of antibiotics. One non-random...Continue Reading

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Citations

Feb 13, 2019·Aesthetic Surgery Journal·Eric Swanson
Jun 28, 2019·Plastic and Reconstructive Surgery·Eric Swanson
Jun 28, 2019·Plastic and Reconstructive Surgery·William P Adams, M Bradley Calobrace
Jul 25, 2019·Plastic and Reconstructive Surgery. Global Open·Eric Swanson
Jun 27, 2020·Plastic and Reconstructive Surgery·Eric Swanson
Aug 21, 2021·Plastic and Reconstructive Surgery·Fouad SaegJeffrey E Janis
Nov 2, 2021·Annals of Plastic Surgery·Eric Swanson

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