Antibiotic-loaded polypropylene surgical meshes with suitable biological behaviour by plasma functionalization and polymerization

Biomaterials
C LabayCristina Canal

Abstract

Hernia repair is one of the most common operations in general surgery, and its associated complications typically relate to infections, among others. The loading of antibiotics to surgical meshes to deliver them locally in the abdominal hernia repair site can be one way to manage infections associated with surgical implants. However, the amount of drug loaded is restricted by the low wettability of polypropylene (PP). In this work, plasma has been used to tailor the surface properties of PP meshes to obtain high loading of ampicillin while conserving the desired biological properties of the unmodified samples and conferring them with antibacterial activity. It was demonstrated that the new surface chemistry and improved wettability led to 3-fold higher antibiotic loading. Subsequently, a PEG-like dry coating was deposited from tetraglyme with low-pressure plasma which allowed maintaining the high drug loading and kept cell properties such as chemotaxis, adhesion and morphology to the same levels as the untreated ones which have shown long-standing clinical success.

References

Apr 1, 1992·Journal of Biomedical Materials Research·G P LópezT A Horbett
Nov 1, 1987·Antimicrobial Agents and Chemotherapy·K A Neftel, U Hübscher
Nov 4, 1969·Journal of Medical Microbiology·D Greenwood, F O'Grady
Aug 1, 1980·International Journal of Cancer. Journal International Du Cancer·S TsuchiyaK Tada
Aug 5, 1998·Biomaterials·M ZhangM Ferrari
Aug 6, 2002·Journal of Biomaterials Science. Polymer Edition·Mingchao ShenThomas A Horbett
Jul 5, 2003·The Journal of Surgical Research·James R DunneLena M Napolitano
Sep 25, 2003·Hernia : the Journal of Hernias and Abdominal Wall Surgery·Angel CeldránJosé F Señarís
Oct 16, 2003·The Journal of Surgical Research·Brent D MatthewsB Todd Heniford
Feb 12, 2004·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·M J HungE S C Ho
Apr 27, 2004·The New England Journal of Medicine·Leigh NeumayerUNKNOWN Veterans Affairs Cooperative Studies Program 456 Investigators
Jun 9, 2004·Journal of Clinical Microbiology·Muhammad R Sohail, Jerry D Smilack
Mar 1, 2005·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Astrid RoosjenHenk J Busscher
Dec 14, 2005·Langmuir : the ACS Journal of Surfaces and Colloids·Roger MichelDavid G Castner
Feb 20, 2007·Biomaterials·Anton F EngelsmanHenk J Busscher
Apr 12, 2007·Biomacromolecules·El-Refaie KenawyRoy Broughton
Oct 23, 2008·International Journal of Pharmaceutics·C CanalA Ricard
Aug 1, 2009·Advanced Drug Delivery Reviews·Hyuk Sang YooTae Gwan Park
Jun 12, 2010·The Journal of Surgical Research·Karem C HarthHorst A von Recum
Nov 26, 2010·Journal of Biomedical Materials Research. Part a·Luisa Mayorga SzottThomas A Horbett
Dec 1, 2010·Journal of the American College of Surgeons·Corey R DeekenBrent D Matthews
Jun 13, 2012·The Journal of Surgical Research·Manuel López-CanoMaria Antonia Arbós
Aug 21, 2012·Journal of Controlled Release : Official Journal of the Controlled Release Society·Olivier GuillaumeJean Coudane
Jan 19, 2013·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Dale W BratzlerUNKNOWN Society for Healthcare Epidemiology of America
Feb 5, 2013·Langmuir : the ACS Journal of Surfaces and Colloids·Andrew MichelmoreRobert D Short
Mar 7, 2013·Surgical Infections·Dale W BratzlerUNKNOWN Society for Healthcare Epidemiology of America (SHEA)

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Citations

Jan 24, 2017·Experimental Biology and Medicine·Erika L Cyphert, Horst A von Recum
Jan 31, 2017·Colloids and Surfaces. B, Biointerfaces·Judit Buxadera-PalomeroDaniel Rodríguez
Nov 24, 2018·Advanced Healthcare Materials·Carlos Mas-MorunoMatthew J Dalby
Jan 16, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Sonia LanzalacoElaine Armelin
Mar 1, 2019·International Journal of Biological Macromolecules·Liangbin XiaHongbing Deng
Mar 30, 2017·Bioactive Materials·Surge KalabaJian Yang
May 11, 2021·Progress in Polymer Science·Chuanlong MaKostya Ken Ostrikov
May 23, 2021·Journal of Biomedical Materials Research. Part a·Ángel Serrano-Aroca, Salvador Pous-Serrano
Jun 4, 2021·Journal of Biomedical Materials Research. Part a·Tanushree SahaXin Wang
Aug 11, 2021·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Brinta BhattacharjeeJayanta Haldar
Jun 15, 2019·ACS Applied Materials & Interfaces·Pengbi LiuXuejun Wen

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