Antibiotic management of urinary tract infection in elderly patients in primary care and its association with bloodstream infections and all cause mortality: population based cohort study

BMJ : British Medical Journal
Myriam GharbiPaul Aylin

Abstract

To evaluate the association between antibiotic treatment for urinary tract infection (UTI) and severe adverse outcomes in elderly patients in primary care. Retrospective population based cohort study. Clinical Practice Research Datalink (2007-15) primary care records linked to hospital episode statistics and death records in England. 157 264 adults aged 65 years or older presenting to a general practitioner with at least one diagnosis of suspected or confirmed lower UTI from November 2007 to May 2015. Bloodstream infection, hospital admission, and all cause mortality within 60 days after the index UTI diagnosis. Among 312 896 UTI episodes (157 264 unique patients), 7.2% (n=22 534) did not have a record of antibiotics being prescribed and 6.2% (n=19 292) showed a delay in antibiotic prescribing. 1539 episodes of bloodstream infection (0.5%) were recorded within 60 days after the initial UTI. The rate of bloodstream infection was significantly higher among those patients not prescribed an antibiotic (2.9%; n=647) and those recorded as revisiting the general practitioner within seven days of the initial consultation for an antibiotic prescription compared with those given a prescription for an antibiotic at the initial consultatio...Continue Reading

References

Apr 28, 1990·BMJ : British Medical Journal·J Chisholm
Sep 14, 2000·Age and Ageing·M E McMurdo, N D Gillespie
Dec 5, 2003·The Journal of Hospital Infection·C M PelloweUNKNOWN Guideline Development Group
Apr 23, 2005·The Journal of Infection·Sari TalAlexander Gurevich
Dec 24, 2005·Critical Care Medicine·Greg S MartinMarc Moss
Jul 23, 2008·The Cochrane Database of Systematic Reviews·Monika Lutters, Nicole B Vogt-Ferrier
Feb 9, 2010·BMJ : British Medical Journal·G M LeydonUNKNOWN UTIS team
Mar 13, 2013·Antimicrobial Agents and Chemotherapy·Kevin A BrownDavid N Fisman
Apr 27, 2013·The Journal of Antimicrobial Chemotherapy·Abhishek DeshpandeCurtis J Donskey
Jan 21, 2014·The Lancet Infectious Diseases·Paul LittleUNKNOWN DESCARTE investigators
Jan 28, 2014·Journal of the American Medical Directors Association·David A NaceChristopher J Crnich
Feb 27, 2014·JAMA : the Journal of the American Medical Association·Lona Mody, Manisha Juthani-Mehta
Jun 8, 2015·International Journal of Epidemiology·Emily HerrettLiam Smeeth
Dec 25, 2015·BMJ : British Medical Journal·Ildikó GágyorEva Hummers-Pradier
Jan 1, 2014·BMJ Quality Improvement Reports·Vee Han LimSieu Ming Ng
Jan 1, 2014·Antibiotics·Lilian M Abbo, Thomas M Hooton
Jun 28, 2017·Journal of the American Geriatrics Society·Christopher J CrnichDavid A Nace
Feb 14, 2018·BMJ : British Medical Journal·Elizabeth CrellinLaurie A Tomlinson
Oct 20, 2018·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Violeta BalinskaitePaul Aylin

❮ Previous
Next ❯

Citations

Mar 1, 2019·BMJ : British Medical Journal·Zosia Kmietowicz
Mar 1, 2019·BMJ : British Medical Journal·Alastair D Hay
Dec 5, 2019·Expert Review of Anti-infective Therapy·Nicola PetrosilloFabrizio Taglietti
Dec 26, 2019·Journal of Evaluation in Clinical Practice·Andrew DaveyParker Magin
Dec 10, 2019·British Medical Bulletin·Eleanor MitchellAnthony Roberts
Nov 22, 2019·Journal of the American Geriatrics Society·Michael S PuliaThomas T Yoshikawa
Dec 5, 2019·European Journal of Hospital Pharmacy. Science and Practice·András SüleStephanie Kohl
May 29, 2020·Nursing Older People·Jane McNeish, Abigail Mullings
Sep 6, 2019·Aging Clinical and Experimental Research·Yaara Leibovici-WeissmanDafna Yahav
Sep 15, 2020·Journal of Primary Care & Community Health·Ludmila Kosheleva, Irene Ngune
Apr 4, 2019·BMJ : British Medical Journal·H Gilbert Welch
Mar 27, 2019·MMW Fortschritte der Medizin·UNKNOWN Springer Medizin
Dec 1, 2019·BMC Geriatrics·Alex SmithsonMaria Teresa Bastida
May 1, 2020·Antibiotics·Ilse WolterinkAlma van de Pol
Sep 7, 2020·Gastrointestinal Endoscopy Clinics of North America·Jia-Yia Liu, Jana K Dickter
Feb 18, 2021·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Bradley J LangfordNick Daneman
Mar 27, 2021·British Journal of Nursing : BJN·Justine Dexter, Gerri Mortimore
Mar 11, 2021·The British Journal of General Practice : the Journal of the Royal College of General Practitioners·Emma Rezel-PottsMartin C Gulliford
May 20, 2021·Current Opinion in Urology·Laila SchneidewindZafer Tandogdu
Jun 3, 2021·Journal of Clinical Medicine·Domingo Palacios-CeñaMarta Lopez-Herranz
Jun 17, 2021·Nature Reviews. Urology·Ines AmbiteCatharina Svanborg

❮ Previous
Next ❯

Software Mentioned

STATA

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.