PMID: 9193864Mar 1, 1997Paper

Antibiotic penetration in the respiratory tract and implications for the selection of antimicrobial therapy

Current Opinion in Pulmonary Medicine
D Honeybourne

Abstract

There has been an increasing amount of information published recently about the ability of different antimicrobial agents to penetrate specific areas of the lung. Initially, whole lung concentrations were reported, but this methodology has been refined so that levels are now measured in potential sites of infection, such as the bronchial mucosa, epithelial lining fluid, and alveolar macrophages, as well as in sputum. Distinct differences in the ability to concentrate in these sites have been shown among beta-lactams, quinolones, and macrolides. Considerable intracellular concentration of quinolones and macrolides, but not beta-lactams, occurs. This intracellular accumulation has been used for the treatment of atypical mycobacteria. The potential effects of high antibiotic levels on cellular function have also been investigated. The clinical relevance of these findings for the choice of antimicrobial agent, dosage, formulation (eg, liposomal), and route of administration (eg, nebulized) are increasingly being explored.

Citations

Oct 16, 2001·Antimicrobial Agents and Chemotherapy·C Muller-SerieysA Andremont
Oct 25, 2003·Antimicrobial Agents and Chemotherapy·M A ZeitlingerC Joukhadar
Apr 28, 2006·Antimicrobial Agents and Chemotherapy·Blair CapitanoRaman Venkataramanan
Nov 20, 2001·Thorax·UNKNOWN British Thoracic Society Standards of Care Committee
May 2, 2012·Critical Care : the Official Journal of the Critical Care Forum·Pieter R TuinmanMarcus J Schultz
Nov 12, 2013·Pulmonary Pharmacology & Therapeutics·Hui HuangZuojun Xu
Jan 15, 2004·American Journal of Respiratory Medicine : Drugs, Devices, and Other Interventions·Mario CazzolaSerafino A Marsico
May 4, 2006·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·B A Cunha
Jun 9, 2004·Diagnostic Microbiology and Infectious Disease·Naomi F Florea, Charles H Nightingale
Nov 28, 2006·Pulmonary Pharmacology & Therapeutics·Junko KikuchiMasaharu Nishimura
Dec 16, 2016·Journal of Aerosol Medicine and Pulmonary Drug Delivery·Florry E van den BoogaardMarcus J Schultz

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