Antibiotic prevention of postcataract endophthalmitis: a systematic review and meta-analysis

Acta Ophthalmologica
Line KesselJesper Hjortdal

Abstract

Endophthalmitis is one of the most feared complications after cataract surgery. The aim of this systematic review was to evaluate the effect of intracameral and topical antibiotics on the prevention of endophthalmitis after cataract surgery. A systematic literature review in the MEDLINE, CINAHL, Cochrane Library and EMBASE databases revealed one randomized trial and 17 observational studies concerning the prophylactic effect of intracameral antibiotic administration on the rate of endophthalmitis after cataract surgery. The effect of topical antibiotics on endophthalmitis rate was reported by one randomized trial and one observational study. The quality and design of the included studies were analysed using the Cochrane risk of bias tool. The quality of the evidence was evaluated using the GRADE approach. We found high-to-moderate quality evidence for a marked reduction in the risk of endophthalmitis with the use of intracameral antibiotic administration of cefazolin, cefuroxime and moxifloxacin, whereas no effect was found with the use of topical antibiotics or intracameral vancomycin. Endophthalmitis occurred on average in one of 2855 surgeries when intracameral antibiotics were used compared to one of 485 surgeries when intr...Continue Reading

References

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Citations

Mar 8, 2016·Health Research Policy and Systems·Kirsti MalterudKari Tove Elvbakken
Feb 28, 2016·American Journal of Ophthalmology·Ella H LeungLaura C Huang
Sep 10, 2015·Journal of Ophthalmology·Line KesselJesper Hjortdal
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Dec 15, 2016·Acta Ophthalmologica·Line KesselJesper Hjortdal
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