Abstract
To evaluate the effect of antibiotic prophylaxis in pacemaker surgery, 100 patients were randomly assigned to a prophylaxis group receiving cloxacillin or to a control group with no antibiotics. Cloxacillin was given intravenously (2 g) 2 hours before operation, followed by 1 g every 6 hours for 2 days and the same dose perorally for 8 more days postoperatively. Adequate plasma concentrations were obtained in all patients. The follow-up time was 1-43 months. The infection rate was 2% (1/50) in the prophylaxis group and 14% (7/50) in the control group (p less than 0.05). The interval from operation to manifest infection was 9-35 days. In the control group the causal microorganism was Staphylococcus aureus in two patients, Staphylococcus epidermidis in two and unknown in three patients. In the only patient with infection in the prophylaxis group, a methicillin-resistant S. epidermidis was isolated. Infection was initially localized to the pacemaker pocket in seven patients, but septicemia developed in one of them and endocarditis in another. In one patient septicemia appeared initially, without local signs of infection. This study suggests that cloxacillin prophylaxis is of value in routine pacemaker surgery.
References
Jan 1, 1977·Acta Orthopaedica Scandinavica·A K CarlssonL Lindberg
Nov 1, 1977·Immunochemistry·J Hiernaux
Jun 1, 1976·Antimicrobial Agents and Chemotherapy·L D SabathM Finland
Dec 1, 1975·The British Journal of Surgery·H Siddons, K Nowak
Jan 1, 1974·Chemotherapy·T Bergan, B Oydvin
Nov 1, 1974·British Heart Journal·B M Kennelly, L W Piller
Jun 1, 1972·European Journal of Clinical Pharmacology·B JallingL O Boréus
Oct 30, 1969·Annals of the New York Academy of Sciences·O Edhag, H Lagergren
Nov 1, 1968·The Annals of Thoracic Surgery·W B FirorM Mori
Mar 1, 1982·Pacing and Clinical Electrophysiology : PACE·B WohlM Fisher
Jul 1, 1983·Pacing and Clinical Electrophysiology : PACE·J Rajs
Jan 1, 1982·Scandinavian Journal of Thoracic and Cardiovascular Surgery·G BluhmC Olin
May 1, 1964·Journal of General Microbiology·M BARBER
Citations
Jan 5, 2000·The Annals of Thoracic Surgery·E AltA Schömig
Apr 14, 2000·La Revue de médecine interne·A Da CostaP Touboul
Oct 1, 1994·British Heart Journal·J P MounseyR S Bexton
Jul 5, 2015·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Gareth J PadfieldAndrew D Krahn
Sep 6, 2012·Pacing and Clinical Electrophysiology : PACE·Rabih DarouicheJeffrey Voigt
Apr 29, 2014·Pacing and Clinical Electrophysiology : PACE·Janek M SenaratneManohara P J Senaratne
Nov 21, 2002·The Annals of Thoracic Surgery·Makoto YamadaToshihiro Takaba
May 1, 2015·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Konstantinos A PolyzosMatthew E Falagas
Dec 1, 1990·Journal of the American Geriatrics Society·T T Yoshikawa
Oct 31, 2015·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Panagiotis KorantzopoulosJohn A Goudevenos
Jan 1, 1988·The Annals of Thoracic Surgery·A B KaiserM R Petracek
Jan 1, 1985·Scandinavian Journal of Thoracic and Cardiovascular Surgery·G L Bluhm
Apr 20, 2004·Journal of Cardiovascular Pharmacology and Therapeutics·Mohammad-Reza MovahedCharles S Bryan
Aug 21, 2013·The Cochrane Database of Systematic Reviews·Kurinchi Selvan GurusamyBrian R Davidson
May 29, 1998·Circulation·A Da CostaP Touboul
May 29, 1998·Circulation·A Da CostaP Touboul
Sep 1, 1986·Pacing and Clinical Electrophysiology : PACE·G BluhmU Ransjö
Jan 31, 2006·Pacing and Clinical Electrophysiology : PACE·Emanuele BertagliaPietro Pascotto
Apr 30, 1998·Critical Care Clinics·L I LutwickM W Connolly
Jan 1, 1994·Annales Françaises D'anesthèsie Et De Rèanimation·J J LehotS Estanove