Antibiotic Prophylaxis with Trimethoprim-Sulfamethoxazole versus No Treatment after Mid-to-Distal Hypospadias Repair: A Prospective, Randomized Study

Advances in Urology
Elizabeth B RothTravis W Groth

Abstract

To evaluate the impact of prophylactic antibiotics after distal hypospadias repair on postoperative bacteriuria, symptomatic urinary tract infection, and postoperative complications in a prospective, randomized trial. Consecutive patients aged 6 months to 2 years were enrolled at our institution between June 2013 and May 2017. Consenting patients were randomized to antibiotic prophylaxis with trimethoprim-sulfamethoxazole versus no antibiotic. Patients had catheterized urine samples obtained at surgery and 6-10 days postoperatively. The primary outcome was bacteriuria and pyuria at postoperative urine collection. Secondary outcomes included symptomatic urinary tract infection and postoperative complications. 70 patients consented to the study, of which 35 were randomized to receive antibiotics compared to 32 who did not. Demographics, severity of hypospadias, and type of repair were similar between the groups. Patients in the treatment group had significantly less pyuria (18%) and bacteriuria (11%) present at stent removal compared to the nontreatment group (55% and 63%; p=0.01 and p < 0.001, resp.). No patient had a symptomatic urinary tract infection. There were 11 postoperative complications. Routine antibiotic prophylaxis a...Continue Reading

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References

May 1, 2004·The Journal of Urology·David Ben Meir, Pinhas M Livne
Jun 12, 2010·Journal of Pediatric Urology·Michael H HsiehEdmond T Gonzales
Feb 19, 2013·The Journal of Urology·Niki KanaroglouWalid A Farhat
Sep 12, 2014·Canadian Urological Association Journal = Journal De L'Association Des Urologues Du Canada·Emilie BaillargeonMohamed El-Sherbiny
May 10, 2016·The Journal of Urology·Said ZeiaiMagdalena Fossum

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Citations

Jan 19, 2022·Hospital Pediatrics·AnnaMaria SalasSarah K Parker

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