Antibiotic Prophylaxis With Trimethoprim/Sulfamethoxazole Instead of Cloxacillin Fails to Improve Inguinal Surgical Site Infection Rate After Vascular Surgery

Vascular and Endovascular Surgery
Julien HasselmannStefan Acosta

Abstract

Surgical site infections (SSIs) and their prevention continue to be a major point of focus in all surgical specialties today. Antibiotic prophylaxis is one of the mainstays in their prevention. Due to the consistently high proportion of infections caused by intestinal flora from the start of our wound surveillance registry in 2005, we conducted a change in prophylactic antibiotic therapy from cloxacillin in 2012 to trimethoprim/sulfamethoxazole (TMP-SMX) in 2013. The study included all patients undergoing vascular surgery with groin incisions between March 1 and June 30 in 2012 and 2013, respectively, whereby the antibiotic regime was changed in between the 2 sampling periods. The diagnosis of SSI was based on clinical examination and microbiological results. Two hundred nineteen patients with inguinal incisions were included in the analysis: 105 in the cloxacillin group of which 19% had SSI and 114 in the TMP-SMX group with an SSI rate of 18% (P = .77), without differences between the 2 groups regarding age, gender, proportion of emergency surgery, type of surgery, or frequency of concomitant foot ulcers. The high proportion of infections caused by intestinal flora between time periods was unchanged (67% vs 81%, P = .34). Ther...Continue Reading

References

Jan 30, 1992·The New England Journal of Medicine·D C ClassenJ P Burke
Oct 30, 1986·The New England Journal of Medicine·A B Kaiser
Sep 1, 1972·Annals of Surgery·D E SzilagyiM P Vrandecic
Dec 2, 1999·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·K B KirklandD J Sexton
Jan 5, 2002·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·R LathamC S Thomas
Oct 13, 2007·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Tobias KühmeLars-Göran Dahlin
Aug 3, 2010·Vascular and Endovascular Surgery·Stone PatrickAsmita Modak
Jan 11, 2012·Seminars in Vascular Surgery·Jean-Baptiste Ricco, Ojan Assadian
Jan 15, 2013·Journal of Vascular Surgery·Somala MohammedPanagiotis Kougias
Feb 26, 2013·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Linda Thimour-BergströmAnders Jeppsson
Apr 17, 2014·Scandinavian Journal of Surgery : SJS : Official Organ for the Finnish Surgical Society and the Scandinavian Surgical Society·J Turtiainen, T Hakala
Jun 24, 2014·Journal of Vascular Surgery·Jeffrey A KalishUNKNOWN Society for Vascular Surgery Patient Safety Organization Arterial Quality Committee

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Citations

Jan 31, 2018·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Robert Svensson-BjörkStefan Acosta
Feb 7, 2019·The British Journal of Surgery·R Svensson-BjörkS Acosta

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