Antibiotic regimens for early-onset neonatal sepsis.

The Cochrane Database of Systematic Reviews
Steven Kwasi KorangJanus C Jakobsen

Abstract

Neonatal sepsis is a major cause of morbidity and mortality. It is the third leading cause of neonatal mortality globally constituting 13% of overall neonatal mortality. Despite the high burden of neonatal sepsis, high-quality evidence in diagnosis and treatment is scarce. Possibly due to the diagnostic challenges of sepsis and the relative immunosuppression of the newborn, many neonates receive antibiotics for suspected sepsis. Antibiotics have become the most used therapeutics in neonatal intensive care units. The last Cochrane Review was updated in 2004. Given the clinical importance, an updated systematic review assessing the effects of different antibiotic regimens for early-onset neonatal sepsis is needed. To assess the beneficial and harmful effects of different antibiotic regimens for early-onset neonatal sepsis. We searched the following electronic databases: CENTRAL (2020, Issue 8); Ovid MEDLINE; Embase Ovid; CINAHL; LILACS; Science Citation Index EXPANDED and Conference Proceedings Citation Index - Science on 12 March 2021. We searched clinical trials databases and the reference lists of retrieved articles for randomised controlled trials (RCTs) and quasi-RCTs. We included RCTs comparing different antibiotic regimens...Continue Reading

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Citations

Oct 21, 2004·The Cochrane Database of Systematic Reviews·E I Mtitimila, R W I Cooke
May 18, 2021·The Cochrane Database of Systematic Reviews·Steven Kwasi KorangJanus C Jakobsen
Nov 3, 2021·The Cochrane Database of Systematic Reviews·Steven Kwasi KorangJanus C Jakobsen

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