Antibiotic regimens for suspected late onset sepsis in newborn infants.

The Cochrane Database of Systematic Reviews
Adrienne Gordon, H E Jeffery

Abstract

Late onset neonatal sepsis (systemic infection after 48 hours of age) continues to be a significant cause of morbidity and mortality. Early treatment with antibiotics is essential as infants can deteriorate rapidly. It is not clear which antibiotic regimen is most suitable for initial treatment of suspected late onset sepsis. To compare the effectiveness and adverse effects of different antibiotic regimens for treatment of suspected late onset sepsis in newborn infants. The standard search strategy of the Cochrane Neonatal Review Group was used. This includes electronic searches of the Cochrane Central Register of Controlled Trials (CENTRAL, The Cochrane Library, Issue 4, 2004), MEDLINE (1966 - Dec 2004), EMBASE (1980 - Dec 2004) and CINAHL (1982 - Dec 2004), electronic abstracts of Pediatric Academic Society meetings (1996 - Dec 2004) and previous reviews including cross references (all articles referenced). Randomised and quasi randomised controlled trials comparing different initial antibiotic regimens in neonates with suspected late onset sepsis were evaluated. Both reviewer authors screened abstracts and papers against the inclusion criteria, appraised the quality of and extracted data from papers. For dichotomous outcomes...Continue Reading

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Citations

Oct 12, 2012·European Journal of Clinical Pharmacology·Chiara PandolfiniMaurizio Bonati
Apr 27, 2010·The Pediatric Infectious Disease Journal·Alison W A TalbertJames A Berkley
Sep 2, 2014·Reproductive Health·Rehana A SalamZulfiqar A Bhutta
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Dec 7, 2019·Systematic Reviews·Steven Kwasi KorangJanus C Jakobsen
Nov 17, 2020·Frontiers in Cellular and Infection Microbiology·Viola SennTanja Restin
May 18, 2021·The Cochrane Database of Systematic Reviews·Steven Kwasi KorangJanus C Jakobsen

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