Antibiotic Resistance Acquisition in the First Week of Life

Frontiers in Microbiology
Olivier BarraudFabien Garnier

Abstract

Objectives: The fetus is considered sterile but recent studies have suggested that gut colonization could start before birth. Scarce data are available for the acquisition of resistant Gram-negative bacteria (GNB) during the first days of life. Several studies have shown that integrons play a major role in antibiotic resistance acquisition. In this work, we studied the dynamics of human intestinal acquisition of GNB and integrons during the first days of life. Methods: Meconium was collected at birth and a stool sample before hospital discharge (days 2 or 3) on 185 term neonates. GNB were searched by culture on each sample and class 1, 2, and 3 integrons from each GNB or directly from samples. Eight risk factors for integron and GNB acquisition were studied. Results: We isolated 228 GNB, 46 from meconium and the remainder from stools. No link was found between GNB isolation and antibiotic exposure during delivery, but antibiotic exposure during labor significantly selected blaTEM-positive amoxicillin-resistant Enterobacteria. Two-thirds of GNB were antibiotic-susceptible and most of the resistant isolates were acquired after birth. Integrons were detected in 18 of the 228 GNB isolates from 3 meconium and 20 stools. Antibiotic a...Continue Reading

References

Aug 1, 1977·The Journal of Pediatrics·S S Long, R M Swenson
Mar 1, 1980·Journal of Periodontal Research·K S Kornman, W J Loesche
Apr 27, 2004·Proceedings of the National Academy of Sciences of the United States of America·Sobhan NandiAnne O Summers
Jun 7, 2005·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·S NijssenM Bonten
Sep 28, 2005·Current Microbiology·Esther JiménezJuan M Rodríguez
Apr 25, 2007·Antimicrobial Agents and Chemotherapy·George L DaikosNikolaos Katsilambros
Sep 7, 2007·The Journal of Antimicrobial Chemotherapy·L BrasmeC De Champs
Feb 19, 2008·Research in Microbiology·Esther JiménezJuan M Rodríguez
May 5, 2010·Journal of Infection in Developing Countries·Amy Gassama SowMarie Cécile Ploy
Jun 15, 2010·The Journal of Antimicrobial Chemotherapy·O BarraudM C Ploy
Jul 29, 2010·Physiological Reviews·Inna SekirovB Brett Finlay
Aug 17, 2010·Annual Review of Genetics·Guillaume CambrayDidier Mazel
Nov 22, 2011·Emerging Infectious Diseases·Olivier BarraudMarie-Cécile Ploy
Jul 28, 2013·Beneficial Microbes·E Avershina, K Rudi
May 23, 2014·Drug Discovery Today. Technologies·Jose L Martinez
Aug 19, 2014·International Journal of Antimicrobial Agents·Olivier BarraudMarie-Cécile Ploy
Apr 29, 2016·Journal of Clinical Microbiology·Heidi AndersenDavid B Haslam
Oct 13, 2017·Frontiers in Microbiology·Delphine ChainierMarie-Cécile Ploy

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Methods Mentioned

BETA
PCR
cesarean section

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