PMID: 9189631Jan 1, 1997Paper

Antibiotic resistance: an ecological imbalance

Ciba Foundation Symposium
S B Levy

Abstract

Antibiotic resistance thwarts the treatment of infectious diseases worldwide. Although a number of factors can be identified which contribute to the problem, clearly the antibiotic as a selective agent and the resistance gene as the vehicle of resistance are the two most important, making up a 'drug resistance equation'. Both are needed in order for a clinical problem to arise. Given sufficient time and quantity of antibiotic, drug resistance will eventually appear. But a public health problem is not inevitable if the two components of the drug resistance equation are kept in check. Enhancing the emergence of resistance is the case by which resistance determinants and resistant bacteria can spread locally and globally, selected by widespread use of the same antibiotics in people, animal husbandry and agriculture. Antibiotics are societal drugs. Each individual use contributes to the sum total of society's antibiotic exposure. In a broader sense, the resistance problem is ecological. In the framework of natural competition between susceptible and resistant bacteria, antibiotic use has encouraged growth of the resistant strains, leading to an imbalance in prior relationships between susceptible and resistant bacteria. To restore ...Continue Reading

Citations

Sep 30, 2004·Journal of Food Protection·H Gregg Claycamp, Barry H Hooberman
Jul 18, 2002·Journal of Veterinary Medicine. B, Infectious Diseases and Veterinary Public Health·J SchlegelováD Rysánek
Jul 4, 2002·Emerging Infectious Diseases·Ronald J AshMelissa Morgan
Dec 17, 2009·FEMS Microbiology Ecology·Anne-Mette R GrønvoldRoderick I Mackie
Feb 7, 2016·Central European Journal of Public Health·Milica Paut KusturicaAna Sabo

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