Antibiotic resistance and antibiotic sensitivity based treatment in Helicobacter pylori infection: advantages and outcome

Archives of Disease in Childhood
M E StreetGian Luigi de'Angelis

Abstract

To compare two strategies for the eradication of Helicobacter pylori infection. Groups 1 and 2 each consisted of 75 consecutive patients. Patients in group 1 were treated with two antibiotics based on antibiotic susceptibility testing; those in group 2 received amoxycillin and clarithromycin for eight days, together with either ranitidine or omeprazole. Eradication rate was assessed in both groups six months after treatment. In group 1, H pylori grew in culture in 63/75 cases. Susceptibility testing showed that 35/63 isolates were resistant to metronidazole, 10/63 to clarithromycin, 2/63 to ampicillin, 1/63 to tetracycline, and 5/63 to both clarithromycin and metronidazole. In group 1 the infection was eradicated in 96% of the initial 75 subjects, and in 98% of the subjects treated according to the antibiotic assay (62/63). As two patients were lost at follow up the overall eradication rate was 99%. In group 2, eradication was achieved in 61/75 subjects (81%). This was significantly lower than the percentage of eradication observed in group 1 (81% versus 99%). Antibiotic susceptibility tests are useful in childhood as a very high percentage of subjects are cured. This approach is costly, but selective antibiotic treatment contr...Continue Reading

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Citations

Mar 26, 2011·Internal and Emergency Medicine·Amin Talebi Bezmin AbadiAshraf Mohabbati Mobarez
Jul 31, 2003·Journal of Paediatrics and Child Health·S RerksuppapholP Ward
Aug 29, 2002·Helicobacter·Eleftheria Roma-Giannikou, Peter L Shcherbakov
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