Antibiotic resistance of pathogenic Acinetobacter species and emerging combination therapy

The Journal of Microbiology
Bora Shin, Woojun Park

Abstract

The increasing antibiotic resistance of Acinetobacter species in both natural and hospital environments has become a serious problem worldwide in recent decades. Because of both intrinsic and acquired antimicrobial resistance (AMR) against last-resort antibiotics such as carbapenems, novel therapeutics are urgently required to treat Acinetobacter-associated infectious diseases. Among the many pathogenic Acinetobacter species, A. baumannii has been reported to be resistant to all classes of antibiotics and contains many AMR genes, such as bla ADC (Acinetobacter-derived cephalosporinase). The AMR of pathogenic Acinetobacter species is the result of several different mechanisms, including active efflux pumps, mutations in antibiotic targets, antibiotic modification, and low antibiotic membrane permeability. To overcome the limitations of existing drugs, combination theraphy that can increase the activity of antibiotics should be considered in the treatment of Acinetobacter infections. Understanding the molecular mechanisms behind Acinetobacter AMR resistance will provide vital information for drug development and therapeutic strategies using combination treatment. Here, we summarize the classic mechanisms of Acinetobacter AMR, alo...Continue Reading

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Citations

Jul 20, 2018·Expert Review of Anti-infective Therapy·Richard R Watkins
Sep 12, 2019·Revista Da Sociedade Brasileira De Medicina Tropical·Fareeha HameedTayyab Ur Rehman
May 10, 2020·Biomolecules·Maria Soledad RamirezMarcelo E Tolmasky
Apr 23, 2020·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·Mustafa SadekPatrice Nordmann
Dec 7, 2018·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·Mathilde LescatPatrice Nordmann
Jan 5, 2020·Applied Microbiology and Biotechnology·Bora ShinWoojun Park
Dec 24, 2018·Expert Opinion on Pharmacotherapy·Reenu ThomasDaniele Dona'
Dec 16, 2020·Diagnostic Microbiology and Infectious Disease·Mustafa SadekPatrice Nordmann

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