Antibiotic Resistance Profile, Outer Membrane Proteins, Virulence Factors and Genome Sequence Analysis Reveal Clinical Isolates of Enterobacter Are Potential Pathogens Compared to Environmental Isolates.

Frontiers in Cellular and Infection Microbiology
Mitali MishraHarapriya Mohapatra

Abstract

Outer membrane proteins (OMPs) of gram-negative bacteria play an important role in mediating antibacterial resistance, bacterial virulence and thus affect pathogenic ability of the bacteria. Over the years, prevalence of environmental antibiotic resistant organisms, their transmission to clinics and ability to transfer resistance genes, have been studied extensively. Nevertheless, how successful environmental bacteria can be in establishing as pathogenic bacteria under clinical setting, is less addressed. In the present study, we utilized an integrated approach of investigating the antibiotic resistance profile, presence of outer membrane proteins and virulence factors to understand extent of threat posed due to multidrug resistant environmental Enterobacter isolates. Also, we investigated clinical Enterobacter isolates and compared the results thereof. Results of the study showed that multidrug resistant environmental Enterobacter isolates lacked OmpC, lacked cell invasion abilities and exhibited low reactive oxygen species (ROS) production in neutrophils. In contrast, clinical isolates possessed OmpF, exhibited high invasive and adhesive property and produced higher amounts of ROS in neutrophils. These attributes indicated li...Continue Reading

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Citations

Oct 12, 2020·Archives of Microbiology·Alazea M TamezJinSong Zheng
Dec 3, 2020·Expert Review of Anti-infective Therapy·Amrita PatilSunil Saroj
Jan 23, 2021·European Biophysics Journal : EBJ·Fatma Dogan GuzelMathias Winterhalter
Feb 6, 2021·Pathogens·Gustavo Henrique Rodrigues Vale de MacedoLuís Cláudio Nascimento da Silva
Jun 14, 2021·Microbial Pathogenesis·Hafiz Iftikhar HussainKun Li

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Methods Mentioned

BETA
PCR
FACS

Software Mentioned

GraphPad Prism
CellQuest Pro
Bionumerics
Bionumeric
XLSTAT

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