Antibiotic-Resistant Escherichia coli and Class 1 Integrons in Humans, Domestic Animals, and Wild Primates in Rural Uganda

Applied and Environmental Microbiology
Debora WeissTony L Goldberg

Abstract

Antibiotic resistance is a global concern, although it has been studied most extensively in developed countries. We studied Escherichia coli and class 1 integrons in western Uganda by analyzing 1,685 isolates from people, domestic animals, and wild nonhuman primates near two national parks. Overall, 499 isolates (29.6%) were resistant to at least one of 11 antibiotics tested. The frequency of resistance reached 20.3% of isolates for trimethoprim-sulfamethoxazole but was nearly zero for the less commonly available antibiotics ciprofloxacin (0.4%), gentamicin (0.2%), and ceftiofur (0.1%). The frequency of resistance was 57.4% in isolates from people, 19.5% in isolates from domestic animals, and 16.3% in isolates from wild nonhuman primates. Isolates of livestock and primate origin displayed multidrug resistance patterns identical to those of human-origin isolates. The percentage of resistant isolates in people was higher near Kibale National Park (64.3%) than near Bwindi Impenetrable National Park (34.6%), perhaps reflecting local socioeconomic or ecological conditions. Across antibiotics, resistance correlated negatively with the local price of the antibiotic, with the most expensive antibiotics (nalidixic acid and ciprofloxacin...Continue Reading

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Citations

Sep 15, 2020·Microbial Genomics·Ebenezer Foster-NyarkoMark J Pallen
Mar 28, 2019·Tropical Animal Health and Production·Sanaz DehdashtiMohammad Rahim Haji Hajikolaei
Jun 30, 2019·EcoHealth·Allison White, James M Hughes
Mar 12, 2021·The Journal of Veterinary Medical Science·Yukino Tamamura-AndohMasahiro Kusumoto
Sep 28, 2021·Frontiers in Veterinary Science·Michel Mainack DioneBarbara Wieland
Nov 16, 2021·Frontiers in Veterinary Science·Cristina Fernández RivasDeborah V Hoyle

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