PMID: 2510054Jan 1, 1989Paper

Antibiotic single-dose prophylaxis of shunt infections

Neurosurgical Review
J BlumD Voth

Abstract

Shunt infections after implantation or revision of a shunt for CSF drainage in hydrocephalic patients are serious complications. In view of their frequency, this study investigated the efficacy of prophylactic administration of a single dose of the antibiotic cefazedone in reducing in the post-operative infection rate. Fifty children of up to 14 years of age suffering from hydrocephalus of various etiologies were treated prophylactically and compared with a similar untreated group. The diagnosis of infection was based mainly on microbiological and clinical observations and investigations. Classical infection parameters were also recorded and evaluated, but played only a secondary role in establishing the diagnosis as they can change post-operatively without an infection being present. The infection rates observed were 6% in the group of patients who received antibiotic treatment prophylactically and 14% in the untreated control group.

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Citations

Jan 1, 1995·Acta neurochirurgica·B M BorgbjergS E Børgesen
May 19, 2006·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·N BiyaniS Constantini
Nov 17, 2001·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·K E LykeT M Perl
Mar 7, 2013·Surgical Infections·Dale W BratzlerUNKNOWN Society for Healthcare Epidemiology of America (SHEA)
Jul 1, 1992·Journal of Neurosurgery·I K PopleR D Hayward
Mar 21, 2008·Journal of Neurosurgery. Pediatrics·Bernardo RatilalCristina Sampaio
Jan 1, 1993·Acta neurochirurgica·T MindermannO Gratzl
Oct 27, 2015·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·H XuT Lei
May 9, 2015·Journal of Neurosurgery. Pediatrics·William C Gump
May 20, 2015·Journal of Neurosurgery. Pediatrics·Paul KlimoUNKNOWN Pediatric Hydrocephalus Systematic Review and Evidence-Based Guidelines Task Force
Sep 14, 2006·Clinical Pediatrics·Ann-Christine Duhaime
Jul 21, 2006·The Cochrane Database of Systematic Reviews·B RatilalC Sampaio
Jan 19, 2013·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Dale W BratzlerUNKNOWN Society for Healthcare Epidemiology of America

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