Antibiotic Susceptibility Evaluation of Group A Streptococcus Isolated from Children with Pharyngitis: A Study from Iran

Infection & chemotherapy
Shirin SayyahfarSara Tavassoli

Abstract

The aim of this study was to evaluate the antibiotic susceptibility of Group A streptococcus (GAS) to antibiotics usually used in Iran for treatment of GAS pharyngitis in children. From 2011 to 2013, children 3-15 years of age with acute tonsillopharyngitis who attended Mofid Children's Hospital clinics and emergency ward and did not meet the exclusion criteria were enrolled in a prospective study in a sequential manner. The isolates strains from throat culture were identified as GAS by colony morphology, gram staining, beta hemolysis on blood agar, sensitivity to bacitracin, a positive pyrrolidonyl aminopeptidase (PYR) test result, and the presence of Lancefield A antigen determined by agglutination test. Antimicrobial susceptibility was identified by both disk diffusion and broth dilution methods. From 200 children enrolled in this study, 59 (30%) cases were culture positive for GAS. All isolates were sensitive to penicillin G. The prevalence of erythromycin, azithromycin, and clarithromycin resistance by broth dilution method was 33.9%, 57.6%, and 33.9%, respectively. Surprisingly, 8.4% of GAS strains were resistant to rifampin. In this study, 13.5% and 32.2% of the strains were resistant to clindamycin and ofloxacin, respec...Continue Reading

References

Feb 10, 1999·The Pediatric Infectious Disease Journal·H J Hamrick, M E Mangum
Apr 30, 1999·Emerging Infectious Diseases·R FacklamG Tyrrell
Apr 4, 2003·International Journal of Antimicrobial Agents·Milan Cizman
Jul 29, 2003·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·M R FazeliB Khodabakhshi
Jul 23, 2004·The Journal of Antimicrobial Chemotherapy·Sunjoo Kim, Nam Yong Lee
Aug 26, 2004·Antimicrobial Agents and Chemotherapy·Edouard BingenRobert Cohen
Aug 5, 2005·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Sandra S RichterGary V Doern
Aug 29, 2006·Seminars in Pediatric Infectious Diseases·Judith M Martin, Michael Green
Nov 15, 2008·Indian Journal of Medical Sciences·Amita JainRashmi Kumar
Apr 28, 2009·Diagnostic Microbiology and Infectious Disease·Athanasios G MichosVassiliki P Syriopoulou
Jul 21, 2012·The Journal of Antimicrobial Chemotherapy·Liesbet Van HeirstraetenSurbhi Malhotra-Kumar
Sep 12, 2012·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Stanford T ShulmanUNKNOWN Infectious Diseases Society of America
Jan 31, 2014·Journal of Clinical Microbiology·Chia-Ying HuangTsai-Ling Yang Lauderdale

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