Antibiotic susceptibility of type b Haemophilus influenzae and Streptococcus pneumoniae, and antibiotic concentration in cerebrospinal fluid

Acta Paediatrica Japonica; Overseas Edition
K FujitaH Yoshioka

Abstract

Antibiotic susceptibilities of 38 type b Haemophilus influenzae and 28 Streptococcus pneumoniae strains isolated from cerebrospinal fluid, blood and other specimens between 1973 and 1988 were studied. Minimal inhibitory concentrations (MICs) of ampicillin against 10 beta-lactamase positive and 28 negative H. influenzae isolates were 32-64 and 0.25 micrograms/ml, respectively. The MIC of chloramphenicol against one of the beta-lactamase positive H. influenzae strains was 8 but MICs against the rest of the organisms were 0.5-1 micrograms/ml. MICs of cefotaxime, ceftriaxone and cefuroxime against all H. influenzae strains were 0.016, 0.008 and 0.5 micrograms/ml, respectively. No S. pneumoniae isolates were resistant to penicillin G and MICs of this drug were 0.016-0.032 micrograms/ml. MICs of cefotaxime, cefriaxone and cefuroxime against all S. pneumoniae strains were 0.016-0.032, 0.016-0.032 and 0.032-0.063 micrograms/ml, respectively. MICs of chloramphenicol against 15, 4 and 9 of S. pneumoniae isolates were 2, 8 and 16 micrograms/ml, respectively. Antibiotic concentrations in the cerebrospinal fluid of patients with bacterial meningitis after intravenous administration of ampicillin (50-70 mg/kg x 4/day), penicillin G (31-63 mg...Continue Reading

References

Feb 6, 1988·Lancet·A M Geddes
Feb 1, 1988·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·K MachkaM Powell
Jul 1, 1986·Archives of Disease in Childhood·H GuiscafréO Muñoz
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Sep 1, 1983·Pediatric Infectious Disease·A L Smith
Mar 1, 1984·Pediatric Infectious Disease·M A JacksonG H McCracken

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Citations

Sep 2, 1999·Infectious Disease Clinics of North America·K P Klugman, S A Madhi
Jun 26, 2003·Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy·Yoshiro MorikawaAki Tamaru

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