Abstract
Continuous nationwide surveillance of invasive pneumococcal disease (IPD) was conducted in Germany. A total of 22,208 isolates from invasive pneumococcal disease were collected between July 1, 1992 and June 30, 2013. The present study was conducted to analyze changes in antimicrobial susceptibility and pneumococcal vaccine coverage after the introduction of pneumococcal conjugate vaccination in Germany. Most of the isolates originated from adults ≥16 years (82.5%), while 17.5% were obtained from children <16 years. Penicillin resistance was observed in 7.2% of meningitis cases both among children and adults during the entire study period. In the post-PCV13 period, the resistance rate was 11.3% in children and 10.0% in adults, which is higher than in the pre-PCV7 and post-PCV7 periods. In the non-meningitis group, an overall penicillin nonsusceptibility rate (intermediate resistance and resistance) of 0.5% was detected both among children and adults. Nonsusceptibility rates among children were 6.3% (pre-PCV7), 7.6% (post-PCV7) and 9.0% (post-PCV13). The corresponding nonsusceptibility rates among adults were 4.4%, 6.0% and 7.9%, respectively. Concerning cefotaxime, in meningitis cases 0.8% of all isolates were intermediate and 0...Continue Reading
References
Apr 1, 1992·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·D M Musher
Mar 1, 1981·Reviews of Infectious Diseases·R Austrian
Aug 13, 2002·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Daniel R Feikin, Keith P Klugman
Jan 8, 2003·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·David M Livermore
Nov 10, 2004·International Journal of Medical Microbiology : IJMM·Ralf René Reinert
Jan 25, 2005·International Journal of Antimicrobial Agents·Susan E BeekmannUNKNOWN GRASP Study Group
Jul 20, 2005·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Daniel R FeikinUNKNOWN Active Bacterial Core surveillance/Emerging Infections Program Network
Apr 7, 2006·The New England Journal of Medicine·Moe H KyawUNKNOWN Active Bacterial Core Surveillance of the Emerging Infections Program Network
May 3, 2006·The Journal of Infectious Diseases·Laura L HammittThomas W Hennessy
Feb 1, 2008·Journal of Clinical Microbiology·Michael R JacobsCynthia G Whitney
Nov 22, 2008·The Lancet Infectious Diseases·Ron Dagan, Keith P Klugman
Feb 20, 2009·Journal of Clinical Microbiology·A FenollD Tarragó
May 8, 2009·International Journal of Antimicrobial Agents·Matthias ImöhlMark van der Linden
Jun 13, 2009·The Journal of Antimicrobial Chemotherapy·Lin-Hui SuCheng-Hsun Chiu
May 5, 2010·Antimicrobial Agents and Chemotherapy·Emilio Pérez-TralleroUNKNOWN Spanish Surveillance Group for Respiratory Pathogens
Jul 31, 2010·International Journal of Microbiology·Matthias ImöhlMark van der Linden
Mar 23, 2011·International Journal of Antimicrobial Agents·Christine BleyRalf René Reinert
Jun 9, 2012·Epidemiology and Infection·M C GoossensJ Verhaegen
Sep 8, 2012·BMC Infectious Diseases·Catherine Weil-OlivierLorenzo Mantovani
Dec 19, 2012·Vaccine·Eiman Mokaddas, M John Albert
Dec 18, 2013·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·John D Grabenstein, David J Weber
Feb 12, 2014·BMC Infectious Diseases·Chih-Cheng LaiPo-Ren Hsueh
Feb 12, 2014·PloS One·Gili Regev-YochayUNKNOWN IAIPD study group
Apr 3, 2014·Vaccine·Shalom Ben-ShimolRon Dagan
Jun 16, 2014·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·M ImöhlM van der Linden
Apr 18, 2015·BMC Infectious Diseases·Matthias ImöhlOrhan Aktas
Citations
Sep 14, 2015·International Journal of Medical Microbiology : IJMM·Ulrich VogelMary Slack
Oct 7, 2016·Frontiers in Cellular and Infection Microbiology·Max R Schroeder, David S Stephens
Oct 8, 2016·Critical Care : the Official Journal of the Critical Care Forum·Grete BuchholzMatthias Klein
Oct 6, 2016·F1000Research·Charles Feldman, Ronald Anderson
Oct 28, 2019·Virulence·Nora S LindhauerBernd Schmeck
Apr 19, 2020·Thorax·David SmithRavijyot Saggu
Aug 22, 2020·Pneumologie·M A RoseM van der Linden
Mar 3, 2017·Current Infectious Disease Reports·Francisco Arancibia, Mauricio Ruiz
Sep 19, 2018·Emerging Infectious Diseases·Stephanie PerniciaroMark van der Linden
Aug 28, 2020·Frontiers in Immunology·Isabelle Bekeredjian-Ding
Jul 14, 2017·Pneumonia·Allen C Cheng, Adam W J Jenney
Oct 5, 2019·Expert Review of Vaccines·Myint Tin Tin HtarLuis Jodar
Jan 3, 2019·Infection & chemotherapy·Sofia MarakiGeorge Samonis
Dec 1, 2020·The Journal of Antimicrobial Chemotherapy·Jordi CàmaraCarmen Ardanuy
Jul 15, 2021·Enfermedades infecciosas y microbiología clínica·Abelardo Claudio Fernández ChávezJesús María Aranaz Andrés