Antibiotic therapy for preterm premature rupture of membranes

Clinical Obstetrics and Gynecology
B M Mercer

Abstract

Antibiotic treatment of the patient with preterm premature rupture of membranes remote from term significantly prolongs pregnancy and reduces amnionitis without increasing the risk of cesarean delivery. Antibiotic treatment reduces perinatal infectious morbidity including neonatal sepsis, GBS sepsis, and pneumonia. Stratified analysis of the currently available prospective trials also demonstrates a significant reduction in gestational-dependent morbidity, specifically respiratory distress and intraventricular hemorrhage with treatment. This is supported by a reduction in composite infant morbidity and other gestational age-dependent morbidities in the NICHD-MFMU trial. Although the optimal treatment regimen has not been determined, limited duration broad spectrum antibiotic treatment is justified in the setting of conservative management of pPROM remote from term. The patient with pPROM and documented pulmonary maturity near term may benefit more from expeditious delivery than from expectant management with antibiotics.

References

May 11, 1992·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·J F McCaulJ C Morrison
Mar 1, 1992·American Journal of Obstetrics and Gynecology·B M MercerB M Sibai
Sep 1, 1990·American Journal of Obstetrics and Gynecology·M M JohnstonG I Benrubi
Sep 1, 1988·American Journal of Obstetrics and Gynecology·E AmonK L Arheart
Apr 1, 1966·American Journal of Obstetrics and Gynecology·M C Brelje, D F Kaltreider
Mar 1, 1980·Obstetrics and Gynecology·B G Tutschka, S C Lauchlan
Feb 1, 1994·American Journal of Obstetrics and Gynecology·J M Ernest, L B Givner
Oct 1, 1993·American Journal of Obstetrics and Gynecology·C J LockwoodC L Cetrulo
Oct 1, 1993·American Journal of Obstetrics and Gynecology·J OwenJ C Hauth
Feb 1, 1996·American Journal of Obstetrics and Gynecology·C EgarterM Schemper
Jan 1, 1996·Gynecologic and Obstetric Investigation·L AlmeidaS Bergström
Sep 15, 1963·American Journal of Obstetrics and Gynecology·T B LEBHERZS L ARJE

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Citations

Jun 23, 2000·Obstetrics and Gynecology·R K EdwardsP Duff
Jan 9, 2003·Obstetrics and Gynecology·Brian M Mercer
Aug 2, 2003·Seminars in Perinatology·Brian M MercerUNKNOWN National Institute of Child Health and Human Development Maternal-Fetal Medicine Units Network
Oct 19, 2005·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Chantal J M StewartH Wainwright
Jan 31, 2002·Clinics in Perinatology·H W Kilbride, D W Thibeault
Mar 29, 2002·Mental Retardation and Developmental Disabilities Research Reviews·Luís F GonçalvesRoberto Romero
Feb 22, 2008·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Gunda PristauzUwe Lang

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