PMID: 11904629Mar 21, 2002Paper

Antibiotic therapy for the treatment of preterm labor: a review of the evidence

American Journal of Obstetrics and Gynecology
J M ThorpV Hasselblad

Abstract

The purpose of this study was to evaluate the evidence regarding antibiotics for the treatment of preterm labor. Through dual review, we abstracted study design and masking, definitions of preterm labor and pregnancy outcome, patient inclusion/exclusion characteristics, patient demographic characteristics, drug and cointerventions, and numerous birth, maternal, and neonatal outcome measures. We graded the quality of the individual articles and the strength of the evidence for antibiotic benefit. We abstracted data from 14 randomized trials and 1 observational study. Of these studies, 13 trials met the requirements for a meta-analysis. The meta-analysis demonstrated a mixed outcome pattern with small improvements in pregnancy prolongation, estimated gestational age at birth, and birth weight. Data were insufficient to show a beneficial effect on neonatal morbidity or mortality rates. Treatment of preterm labor with antibiotic therapy can prolong gestation. The benefits of antibiotics are small, and there is considerable uncertainty about the optimal agent, route, dosage, and duration of therapy.

References

Dec 1, 1991·American Journal of Obstetrics and Gynecology·E R NewtonB D Elliott
Oct 1, 1991·American Journal of Obstetrics and Gynecology·J A McGregorK Seo
Feb 1, 1991·American Journal of Obstetrics and Gynecology·D A SavitzJ M Thorp
May 1, 1995·American Journal of Obstetrics and Gynecology·M GordonJ Iams
Mar 1, 1995·JAMA : the Journal of the American Medical Association·A WilcoxJ Kiely
May 1, 1994·British Journal of Obstetrics and Gynaecology·K NormanG Kirsten
Jan 1, 1996·American Journal of Obstetrics and Gynecology·S M CoxK J Leveno
Jan 1, 1996·Gynecologic and Obstetric Investigation·R NadisauskieneA Kilda
Aug 1, 1997·British Journal of Obstetrics and Gynaecology·J SvareJ Kristensen
Feb 7, 2001·Journal of Agricultural and Food Chemistry· Serra Bonvehí J, Ventura Coll F
May 18, 2000·The New England Journal of Medicine·R L GoldenbergW W Andrews

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Citations

Sep 4, 2010·Clinics in Perinatology·Tara M Randis
Jul 5, 2005·Annals of Epidemiology·Martha Slay Wingate, Greg R Alexander
Jan 13, 2005·Obstetrics and Gynecology Clinics of North America·Greg R AlexanderRussell S Kirby
Sep 18, 2007·American Journal of Obstetrics and Gynecology·Greg R AlexanderMichael D Kogan
Jun 26, 2003·American Journal of Obstetrics and Gynecology·Nancy D BerkmanAnjolie E Idicula
May 24, 2005·Archives of Gynecology and Obstetrics·Oliver N RichterJ Schmolling
Jan 24, 2007·Pharmacy World & Science : PWS·Ivanka Orozova-BekkevoldJørn Olsen
Nov 28, 2002·Mental Retardation and Developmental Disabilities Research Reviews·Greg R Alexander, Martha Slay
Oct 18, 2003·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·P FidelR Gomez
Jan 30, 2003·Obstetrical & Gynecological Survey·Anthony O OdiboGeorge A Macones
Jan 27, 2005·Obstetrical & Gynecological Survey·Lisa M Hollier

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